摘要
目的:C-反应蛋白(CRP)和肿瘤坏死因子-α(TNF-α)在慢性肾功能衰竭各期中的水平,探讨两者与肾功的关系。方法:定量检测52例慢性肾功能衰竭患者外周血CRP和TNF-α的水平,并与20例正常健康人作比较,同时检测患者的肾功。并分析TNF-α与血肌酐(SCr)的相关性。结果:CRP在慢性肾功能衰竭各期中均有不同比例的升高,并随着肾功能衰竭的加重比例有升高的趋势。TNF-α在慢性肾功能衰竭各期中均较正常组明显升高,且随着肾功能衰竭的加重有逐渐升高的趋势,同时与SCr成正相关。结论:CRP和TNF-α可能参与慢性肾功能衰竭的发生、发展,并可作为病情监测、预后的重要指标。
AIM:ToassessthelevelsofserumC-reactiveprotein(CRP)andtumornecrosisfactoralpha(TNF-α)inpatientswithchronicrenalfailureandtoinvestigatetherelationshipwithrenalfunction.METHOD:TheconcentrationsofCRPandTNF-αwerequantitativelyas-sessedin52patientswithchronicrenalfailureand20normalageandsex-matchedcontrols.Kidneyfunction,plasmalipids,plasmaalbumenandhemoglobinweremeasuredatthesametime.TherelativityofTNF-αtoserumcreatininewasanalyzed.RESULT:Inchronicrenalfailuregroup,theconcentrationsofCRPandTNF-αweresignificantlyhigherthanthoseinnormalcontrolgroupandin-creasedwiththeaggravateddegreeofrenalfunction.TheconcentrationofTNF-αinchronicrenalfailuregroupwaspositivelycorrelatedwithserumcreatinine.
出处
《中国临床康复》
CAS
CSCD
2003年第21期3023-3024,共2页
Chinese Journal of Clinical Rehabilitation
基金
黑龙江省攻关课题(JC01C145-04)~~
关键词
C-反应蛋白
肿瘤坏死因子
慢性肾功能衰竭
检测
外周血
血肌酐
CRPandTNF-αmaybeassociatedwiththeoccurrence,developmentofchronicrenalfailure,andmaybeasanimportantindicatorofprognosisinmonitoringthepatient'scondition.
