摘要
目的:了解给肾病综合征病人输注白蛋白的不良效应。方法:30例微小病变肾病综合征病人,15例输注人体白蛋白(A组),15例未输注人体白蛋白(B组)。两组患者入院时血浆总蛋白、白蛋白、尿蛋白量、肾功能、肾活检病理类型无差别(P>0.05),强的松治疗方案相同,故两组有可比性。结果:A组达到完全缓解需(45±10)d,B组仅(20±13)d(P<0.05),而且输注白蛋白量越多,达到缓解所需天数越长(P<0.01)。结论:静脉滴注人体白蛋白可促进利尿和缓解肾前性肾功能减退,但盲目应用对微小病变肾病综合征起不利作用。
Objective: To understand the side effect of intravenous albumin in patients with nephrotic syndrome. Methods: Of 30 patients with minimal change disease (MCD), 15 cases were treated by intravenous human albumin (group A), the other half with no such treatment (group B). There was no difference in both groups about plasma total protein and albumin, amount of urinary protein excretion, renal function and pathological changes of kidneys at admission to hospital(P >0.05). The therapy scheme of Prednisone is the same in two groups. Results:The patients in group A completely got remission (CR) after 45 ± 10 days, but the patients in group B only needed 20 ± 13 days(P<0.05). Besides the more quantity of intravenous albumin, the longer days needed to make patients complete remission(P<0.05).Conclusion: Intravenous human albumin can strenghten diur&sis and relieve prerenal failure, but the abuse of intravenous human albumin might cause side effect for MCD patients.
出处
《中国中西医结合肾病杂志》
2003年第8期452-454,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
