双氢青蒿素、防2对间日疟和抗药性恶性疟的预防效果

Evaluation on the effectiveness of dihydroartemisinin or P/S in prevention vivax malaria and drug-resistant falciparum malaria in Yunnan, China

目的 评价双氢青蒿素及防 2对间日疟和抗药性恶性疟的预防效果 ,指导高危人群预防服药。 方法 在云南省边境的勐腊县、景洪市和孟连县发病率≥ 8%的村子 ,随机分成双氢青蒿素 (A、B)组、防 2 (C)组和空白对照(D)组进行预防服药控制疟疾现场研究。 结果 A组带虫率从服药前的 10 40 % ( 5 4/5 91)降到药后的 6 95 % ( 3 7/5 3 3 ) ,下降 3 3 17% ;B组下降 84 70 % ;C组下降 49 82 % ;空白对照组带虫发病率较观察前上升 68 0 0 %。 结论 双氢青蒿素每 15d顿服 6片 ,连续 2月 ,对间日疟和抗药性恶性疟有一定的预防效果 ;防

Objective To evaluate the prophylatic effect of dihydroartemisinin and s/p (sulfadoxin /pyrimethamine) on patients with drug-resistant falciparum malaria and provide guidance for administration of prophylaxis in population at high risk Methods The villages with malaria morbidity of over 8% in Mengla County, Jinghong City and Menglian County at border area of Yunnan Province were chosen and randomly divided into 4 groups : Group A and Group B ( administration of dihydroartemisinin), Group C (administration of sulfadoxin/pyrimethamine) and Group D ( Blank control ) for conducting field study on the control of malaria by drug propylaxis Results The parasite carrying rate in Group A was reduced from 10 40% (54/591) before drug administration to 6 95% (37/533) after drug administration, a drop of 33 17%; the reduction rates in Group B and C were 84 7% and 49 82%, respectively; while the parasite carrying rate in Group D was increased by 68 00% before the study Conclusion Good effectiveness for prevention of vivax malaria and drug-resistant falciparum malaria could be achieved by administration of dihydroarteminisinin in a single dose of 600mg (6 tablets) every 15 days for a period of two months In addition, S/P also has certain effectiveness for preventing vivax malaria