磷酸萘酚喹片对恶性疟和间日疟疗效的观察

Observation on the effectiveness of naphthoquine phosphate tablets on patients with vivax malaria and falciparum malaria.

目的 观察磷酸萘酚喹片治疗恶性疟和间日疟。 方法 磷酸萘酚喹总量 10 0 0mg( 10片 ) 2d分服 ,首剂服 6片 ,第 2d服 4片治疗恶性疟 ,60 0mg顿服治疗间日疟。 结果 恶性疟和间日疟分别治疗 91例和 78例 ,临床治愈率均为 10 0 % ;其退热时间各为 ( 3 3 88± 2 0 3 0 )h和 ( 2 0 3 1± 9 84)h ;疟原虫转阴时间各为 ( 5 4 67± 12 5 6)h和 ( 4 4 5 1± 10 15 )h。完成 2 8d随访 ,恶性疟和间日疟各 64例和 5 0例均无复燃。 结论 磷酸萘酚喹片治疗恶性疟和间日疟具有使用方便、疗效确切、副反应轻等特点。鉴于部分病例退热和原虫转阴时间缓慢 ,建议与青蒿素类速效药物联用 ,取长补短 ,达到减少剂量 。

Objective To make further observation on the therapeutic effectiveness of naphthoquine phosphate tablets on patients with vivax malaria and falciparum malaria Methods Plasmodium falciparum patients were treated with a total dose of 1 000mg (10 tablets), for a course of 2 days, the first day 600mg and the second day 400mg; while Plasmodium viviax patients were treated with a single dose of 600mg Results Totally 169 patients were treated including 91 cases with Plasmodium falciparum and 78 cases with 78 cases with Plasmodium vivax with a clinical cure rate of 100% Fever clearance time for falciparum malaria patients and vivax malaria patients was (33 88±20 30)h and (20 31±9 84)h,respectively; Parasites clearance time for falciparum malaria patients and vivax malaria patients was (54 67±12 56)h and (44 51±10 15)h, respectively No resurgence was observed in 64 falciparum patients and 50 vivax malaria patients after a follow-up of 28 days Conclusion Naphthoquine phosphate tablets is convenient, efficacious for clearance of Plasmodium falciparum and Plasmodium vivax with mild side effect With regard to its relatively slowness in clearance of parasite and fever it is suggested naphthoquine phosphate tablets be combined with other artemisinin in order to reduce the dose, duration of treatment and delay the occurrence of drug resistance