大剂量纳洛酮治疗弥漫性轴索损伤的临床研究

CLINICAL STUDY OF LARGE DOSAGE NALOXONE IN TREATMENT FOR DIFFUSE AXONAL INJURY

目的 :探讨大剂量纳洛酮对弥漫性轴索损伤 (DAI)患者的治疗作用。方法 :大剂量纳洛酮治疗DAI患者5 2例与同等条件下但未用纳洛酮治疗的同类患者 5 2例比较。结果 :纳洛酮实验组恢复良好 15例 (2 8.8% ) ,死亡 13例 (2 5 .0 % ) ,觉醒天数为 (17.5 8± 9.36 ) (n =35 ) ;对照组分别为 7例 (13.5 % )及 2 4例 (4 6 .1% ) ,觉醒天数为 (2 5 .86± 9.85 ) (n =2 2 ) ;两组比较均有显著性差异 (P >0 .0 5 ) ;实验组血浆 β -内啡肽均值较对照组下降明显 (P >0 .0 1)。结论 :DAI早期应用大剂量纳洛酮治疗可降低死亡率 ,提高恢复良好率 ,缩短昏迷时间。治疗过程中未见毒副作用。

Objective:To determine the therapeutic effect of Naloxone (NLX) on diffuse axonal injury (DAI) .Methods:Fifty-two patients were treated with NLX, as many patients treated with no NLX were taken as control. Results:The results showed that 15 cases (28.8%) recovered satisfactorily and 13 cases (25.0%) died in NLX group,while in no NLX group, 7 (13. 5%) and 24 (46.1%) cases respectively. There were significant differences in two groups ( P >0. 05 ); the time of awakening and conscious recovery in NLX group were shorter than that in control ( P >0. 05 ) ;Blood β-EP content in NLX group was significantly decreased compared with that of the control group ( P >0.01). Conclusions:The effect of patients with DAI can be improved by administrating large dosage NLX. Moreover, no side effects and long dated complication is found.