氟伐他汀治疗急性冠脉综合征近期疗效观察

EFFECT OF FLUVASTATIN TREATMENT ON ACUTE CORONARY SYNDROME

目的 :探讨氟伐他汀治疗急性冠脉综合征 (ACS)对低密度脂蛋白胆固醇 (LDL)和近期急性心血管事件发生率的影响。方法 :6 8例ACS患者随机分为氟伐他汀 2 0mg/QN +常规治疗 (氟伐他汀组 ,36例 )及常规治疗(常规治疗组 ,32例 ) ,比较 8周内LDL降低情况及急性心血管事件发生率的差异。结果 :LDL降低情况 :氟伐他汀组治疗后LDL明显下降 ,同治疗前相比差异有显著性 (3.4 2± 0 .81vetsus 4 .6 9± 0 .85mmol/L ,P <0 .0 1) ;而常规治疗组治疗前后差异无显著性 (4 .72± 0 .95versus 4 .4 2± 0 .81mmol/L ,P >0 .0 5 ) ;心血管事件发生率 :常规治疗组 8周内急性心血管事件发生 8例 ,氟伐他汀组为 2例 ,两组相比差异有显著性 (P <0 .0 1)。结论 :ACS患者应用氟伐他汀治疗后 。

Objective:To investigate the effect of fluvastatin on levels of lower density lipoprotein (LDL) and cardiovascular events' incidence in acute coronary syndrome(ACS).Methods:68 patients with ACS were randomly divided into two groups: 32 patients accepted routine treatment ( the control group); the other 36 patients were assigned to routine treatment plus fluvastatin 20mg/QN (the group of fluvastatin).Results:Compared with routine treatment, fluvastatin significcntly decreased the levels of serum lower density lipoprotein (3.42±0.81 versus 4.69±0.85 retool/L, P <0.01 ) ; 8 of 29 patients (27.6%) treated in routine recured cardiovascular events, but only 2 of 36 (6.3%) patients treated with fluvastatin( P <0.01).Conclusions:Fluvastatin can significantly decrease the cardiovascularevent's recurrence in patients of ACS.