^(188)Re-HEDP治疗转移性骨肿瘤疼痛的临床价值

Clinical Value of Using ^(188)Re-HEDP in Treatment of Metastatic Bone Cancer Pain

目的 探讨188Re -HEDP(188铼 - 1-羟基亚乙基二瞵酸盐 )治疗转移性骨肿瘤疼痛的临床价值。方法用188W - 188Re发生器淋洗的188Re示踪剂制备188Re -HEDP ,38例癌骨转移患者用188Re -HEDP治疗 ,观察其疗效。结果 38例经188Re -HEDP治疗后骨痛消失 12例 (31.6 % ) ,骨痛明显减轻 19例 (5 0 % ) ,止痛总有效率为83.7% ;治疗后骨转移灶完全消失 1例 (2 .6 % ) ,转移灶减少或缩小在 5 0 %以上 3例 (7.9% ) ,减少或缩小在 2 5 %以上 5例 (13.2 % ) ,转移灶消失或缩小的总有效率为 2 3.7%。结论 188Re-HEDP对恶性肿瘤多发性骨转移所致疼痛有明显疗效 。

Objective To evaluate the clinical value of using 188 Re-HEDP in treatment of metastatic bone cancer pain. Methods 188 Re-HEDP was synthesized by using 188 Re tracer eluted from 188 W- 188 Re generator. Thirty eight patients with metastatic bone cancer pain were treated using 188 Re-HEDP. The effect of treatment was observed. Results Thirty eight patients with disseminated bone metastases underwent therapy with 188 Re-HEDP. Twelve patients (31.6%) experienced pain disappearance, and pain relief was obtained in 19 patients (50%), so the total efficiency amounted to 81.6%. Bone metastases disappeared in 1 patient(2.1%); the size or the number of metastatic foci decreased over 50% in 3 patients (7.9%); a decrease of the number or the size of metastatic foci over 25% in 5 patients (13.2%) was obtained, the total efficiency being 23.7%. Our results demonstrated that patients with disseminated metastases could be effectively treated by using 188 Re-HEDP. Conclusion The clinical effect of 188 Re-HEDP in treatment of metastatic bone cancer pain is obvious. Application is safety and there are no significant side effects in application of the medicine.