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1型糖尿病疫苗的研究现状 被引量:2

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摘要 目前主要进行的1型糖尿病(T1DM)疫苗研究有自身抗原疫苗、T细胞及其受体疫苗、细胞因子疫苗等。这些疫苗对T1DM的防治具有重要作用,其作用机理主要为重新诱导免疫耐受和促进免疫调节。部分疫苗已开始进行临床试验并取得了一定的成效。
出处 《国外医学(内分泌学分册)》 2003年第4期234-236,共3页 Foreign Medical Sciences(Section of Endocrinology)
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同被引文献11

  • 1陈庆梅,吴国君,吴洁,李泰明,曹荣月,刘景晶.热休克蛋白65及其融合蛋白Hsp65-6×P277的分离纯化和稳定性研究(英文)[J].药物生物技术,2007,14(4):249-254. 被引量:6
  • 2Wilson D B.Immunology:insulin auto-antigenicity in type 1 diabetes[J].Nature,2005,438(7067):E5;discussion E5-6.
  • 3Yang Z,Chen M,Fialkow L B,et al.The novel anti-inflam-matory compound,lisofylline,prevents diabetes in multiple low-dose streptozotocin-treated mice[J].Pancreas,2003,26(4):99-104.
  • 4Mensah-Brown E P,Stosic G S,Maksimovic D,et al.Dow-nregulation of apoptosis in the target tissue prevents low-dose streptozotocin-induced autoimmune diabetes[J].Mol Immunol,2002,38(12-13):941-946.
  • 5Muir A,Peck A,Clare-Salzler M,et al.Insulin immuniz-ation of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription[J].J Clin Invest,1995,95(2):628-634.
  • 6Maron R,Guerau-de-Arellano M,Zhang X,et al.Oral ad-ministration of insulin to neonates suppresses spontaneous and cyclophosphamide induced diabetes in the NOD mouse[J].J Autoimmun,2001,16(1):21-28.
  • 7Hartmann B,Bellmann K,Ghiea I,et al.Oral insulin for diabetes prevention in NOD mice:potentiation by enhancing Th2 cytokine expression in the gut through bacterial adjuvant[J].Diabetologia,1997,40:902-909.
  • 8Sakaguchi S,Sakaguchi N,Shimizu J,et al.Immunologic tolerance maintained by CD+25CD+4 regulatory T cells:their common role in controlling autoimmunity,tumor immunity,and transplantation tolerance[J].Immunol Rev,2001,182:18-32.
  • 9Xue M,Thompson P J,Clifton-Bligh R,et al.Leukocyte matrix metalloproteinase-9 is elevated and contributes to lymphocyte activation in type Ⅰ diabetes[J].Int J Biochem Cell Biol,2005,37(11):2406-2416.
  • 10欧尔班,罗说明,周智广.应用新疫苗预防1型糖尿病[J].糖尿病天地(临床),2011(6):283-287. 被引量:1

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