卵巢上皮癌血清肿瘤标志物联合检测诊断研究

The Study of Combined Serum Tumor Markers in Diagnosis of ovarian epithelial cancer

目的 :探讨血清肿瘤相关抗原CA12 5、CA19 9单独及联合检测在卵巢上皮癌诊断上的价值。方法 :应用化学发光免疫分析法 ,检测 34例卵巢上皮癌患者 ,2 2例卵巢良性肿瘤患者及 30例健康妇女的血清CA12 5、CA19 9含量并进行比较分析。结果 :卵巢上皮癌患者血清CA12 5、CA19 9含量均值分别为 177 2 1± 2 32 0 1,2 30 30± 2 76 31,均高于良性肿瘤患者组及健康妇女对照组。在粘液性囊腺癌中CA19 9阳性检出率为 91 7%,优于CA12 5的阳性检出率 75 %。两者联合检测卵巢上皮癌敏感性、特异性和准确性提高为 88 2 %、98 1%和 94 2 %。结论 :CA12 5、CA19 9联合检测有助于提高卵巢上皮癌的诊断符合率。

Objective To discuss the value of alone and combined detection of CA125 and CA19-9 in the diagnosis of ovarian epithelial cancer.Methods Using the chemiluminescence immunoassay,we measured preoperative serum levels of CA125 and CA19-9 in 34 patients with ovarian epithelial cancer and 22 patients with benign ovarian tumor.We also assayed serum from 30 healthy women.Results The average levels of CA125 and CA19-9 in patients with epithelial ovarian cancer were 177.21±232.01 and 230.30±276.31,and higher than other groupes.CA19-9 was clearly superior in diagnosing mucinous carcinomata,the positive rate was 91.7% versus 75% for CA125.The Combined of the two markers increased the senditivity,specificity and accuracy to 88.2%?98.1% and 94.2%.Conclusion Paralled use of CA125 and CA19-9 could improve the diagnostic accuracy in ovarian epithelial cancer.