期刊文献+

瘦素受体基因多态性研究进展 被引量:4

下载PDF
导出
摘要 瘦素是肥胖基因的产物,主要通过瘦素受体这一中介来调节机体能量代谢及脂肪沉积。瘦素受体在体内分布广泛,其基因存在多种基因型。近年来的研究发现,其基因多态性与肥胖、糖尿病、高血压等疾病的发生发展相关,其中研究较多的为Lys109Arg、Gln223Ser、Lys656Asn这3种多态。
出处 《国外医学(儿科学分册)》 2003年第4期221-223,共3页 Foreign Medical Sciences(Section of Pediatrics)
  • 相关文献

参考文献24

  • 1Zhang Y, Proence R, Maffei M,et al. Positianal cloning of the mouse obese gene and its human homologue[J]. Nature, 1994,372(6505) :425-32.
  • 2Tartaglia LA, Dembski M,Weng X,et al. Identification and expression cloning of a leptin receptor, OB-R[J]. Cell, 1995,83(7) : 1263-71.
  • 3Matsuoka N, Ogawa Y, Hosoda K, et al. Human leptin receptor gene in obese Japanese subject: evidence against either daesity-causing mutations or association of sequence variants with obesity[J]. Diabetologia, 1997,40(10) : 1204-10.
  • 4Wauters M, Mertens I, Rankinen T, et al.Leptin receptor gene polymorphisms are associated with insulin in obese women with impaired glucose tolerance[J].J Clin Endocrinol Metab,2002,86(7):3227-32
  • 5Clement K,Vaisse C,Lahlou N,et al.A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction[J].Nature,1998,392(6674):398-401
  • 6Fukuda H, Iritani N, Sugimoto T, et al. Transcriptional regulation of fatty acid synthase gene by insulin/glucose, polyunsaturated fatty acid and lepfin in hepatocytes and adipocytes in normal and genetically obese rats[J]. Eur J Biochem, 1999,260(2) :505-11.
  • 7Perusse L,Chagnon YC,Weisnagel SJ,et al.The human obesity gene map:the 2000 update[J].Obes Res,2001,9(2):135-68
  • 8Yiannakouris N, Yannakoulia M, Melistas L,et al.The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage d body weight and body composition variability[J] .J Clin Endocrinol Metab,2001,86(9) :4434-9.
  • 9Rand L, Winchester EC, Millwood IY, et al. Matemal leptin receptor gene variant Gln223Arg is not associated with variation in birth weight or matemal body mass index in UK and South Asian populations[J]. Int J Obes Metab Disord,2001,25(5) :753-5.
  • 10Quinton ND,Lee AJ,Ross RJ,et al.A single nucleotide polymorphism(SNP)in the leptin receptor is associated with BMI,fat mass and leptin levels in postmenopausal Caucasian women[J].Hum Genet,2001,108(3):233-6

同被引文献57

引证文献4

二级引证文献15

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部