PTEN蛋白在前列腺癌组织中的表达及其临床意义

Expression of PTEN in Prostate Cancer and its Significance

目的 探讨PTEN蛋白在前列腺癌组织中的表达及其临床意义。方法 应用免疫组织化学S -P方法 ,检测 42例前列腺癌及 2例正常前列腺组织和 5例良性前列腺增生组织中PTEN蛋白的表达。结果 42例前列腺癌组织中 11例 (2 6.2 % )PTEN蛋白表达阳性。随肿瘤细胞病理分级、临床分期的增高 ,PTEN蛋白阳性表达率降低 ,高、中分化组 2 2例中 10例 (4 5 .5 % )PTEN表达阳性 ,低分化组 2 0例中 1例 (5 .0 % )阳性表达 ;A +B期和C +D期前列腺癌组织中的阳性表达率分别为 3 4.5 % (10 /2 9)和 7.7% (1/13 ) ,各组间比较有显著性差异 (χ2 =8.87,P <0 .0 1;χ2 =4.0 3 ,P <0 .0 5 ) ,正常前列腺组织和良性前列腺增生组织中PTEN蛋白均呈阳性表达。结论 PTEN蛋白异常表达在前列腺癌的进展中有重要作用 。

Objective To investigate the expression of PTEN in primary prostate cancer and its clinical significance.Methods PTEN protein expression of 42 prostate cancer,2 normal prostate tissue and 5 benign prostatic hyptertrophy sample were analysed by immunohisochemical staining.Results The positive rate of PTEN was 26.2%(11/42) in primary prostate cancer.The higher the grade and the clinical stage of tumor were,the lower the expression of PTEN.The positive rate of PTEN in well or moderately differentiated type and in poorly differentiated type were 45.5%(10/22) and 5.0%(1/20)(χ 2=8.87,P<0.01) respectively.The positive rates of PENT in A+B stage and in C+D stage were 34.5%(10/29) and 7.7%(1/13)(χ 2=4.03,P<0.05) respectively.But 7 cases with normal and benign lesions all had positive expression of PENT.Conclusion The abnormal expression of PTEN may play an important role in the development of primary prostate cancer.PENT examination is useful for the judgement of tumor development and prognosis.