EP、NP、TP方案治疗晚期非小细胞肺癌的疗效观察

Effect of EP、NP and TP Regimen in the Treatment of Advanced Non-small Cell Lung Cancer

目的 观察比较EP(VP -16+DDP)、NP(NVB +DDP)、TP(Taxol+DDP) 3个联合方案治疗晚期非小细胞肺癌的近期疗效及毒副作用。方法 对 14 3例晚期非小细胞肺癌患者分别采用EP、NP、TP 3个方案治疗 ,其中EP组 41例 ,NP组 68例 ,TP组 3 4例 ,3组病例的临床资料具有可比性。结果 EP组有效率为 2 4.4% (10 /4 1) ,NP组为 44 .1% (3 0 /68) ,TP组为 47.1%(16/3 4)。不良反应主要为骨髓抑制 ,其中Ⅲ～Ⅳ度白细胞减少发生率分别为 2 4.4% (10 /4 1)、3 8.2 % (2 6/68)、2 9.4% (10 /3 4)。结论 NP与TP方案是治疗晚期非小细胞肺癌的有效方案 ,其主要不良反应为骨髓抑制 。

Objective To observe the effect and the toxicity of EP?NP and TP regimen in the treatment of patients with advanced non-small cell lung cancer(NSCLC).Methods 143 cases of NSCLC were studied retrospectively.41 patients were treated with EP,68 patients with NP and 34 patients with TP.Results The overall response rate was 24.4%(10/41) in group EP,44.1%(30/68) in Group NP,and 47.1%(16/34) in group TP.The main side effect was hematologic toxicity.Conclusion NP and TP regimen are very effective chemotherapy for advanced non-small cell lung cancer with tolerable side effects.