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四聚体技术的新进展 被引量：2

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摘要 四聚体技术是一种可直接对抗原特异的T淋巴细胞进行标记的新方法。多种MHC分子和多种来源的多肽分子被用于制备四聚体 ,研究抗原特异的T细胞在抗病毒感染、自身免疫病和抗肿瘤中的作用。另外 。
作者 易绍琼 高杰英
机构地区 军事医学科学院微生物流行病研究所免疫室
出处 《上海免疫学杂志》 CSCD 北大核心 2003年第4期283-285,共3页 Shanghai Journal of Immunology
关键词 四聚体 抗原特异的T细胞
分类号 R392.12 [医药卫生—免疫学]
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参考文献11

  • 1Altman JD, Moss PAH, Goulder PJR, et al. Phenotypic analysis of antigen-specific T lymphocytes [ J ]. Science, 1996,274 : 94.
  • 2Alexis MK, Ear CG, Edith P, et al. A simplified procedure for the preparation of MHC/peptide tetramers:chemieal biotinylation of an unpaired cysteine engineered at the C-terminus of MHC I[J]. J Immunol Methods, 2000,234 : 61.
  • 3Jager E. Hohn H. Necker A, et al. Peptide-specific CD8+ T cell evolution vlvo: response to peptide vaccination with Melan-A/MART-1 [J].Int J Cancer,2002.98:376.
  • 4Echchakir H. Dorothee G, Vergnon I, et al. Cytotoxic T lymphocytes directed against a tumor-specific mutated antigen display similar HLA tetramer binding but distinct functional avidity and tissue distribution[J]. Proc Natl Acad Sci USA,2002,99:9358.
  • 5Liu CP,Jiang K,Wu CH,et al. Detection of glutamic acid decarboxylase-activated T cells with I-Ag7 tetramers[J]. Proc Natl Acad Sci USA, 2000,97 : 14596.
  • 6Tarbell KV,Lee M,Ranheim E,et al. CD4( + ) T cells from glutamic acid decarboxylase (GAD) 65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transfer[J]. J Exp Med,2002,196:481.
  • 7Wilson JD,Ogg GS.Allen RL,et al. Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection [ J ]. AIDS.2000,14:225.
  • 8Callan MF, Tan L, Annels N, et al. Direct visualization of antigen-specific CD8+T cells during the primary immune response to Epstein-Barr virus in vivo[J]. J Exp Med, 1998,187:1395.
  • 9Reignat S, Webster GJ. Brown D, et al. Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection[J]. J Exp Med,2002, 195:1089.
  • 10Novak EJ, Liu AW, Gebe JA, et al. Tetramer-guided epitope mapping:rapid identification and characterization of immunodominant CD4+ T cell epitopes from complex antigens[J]. J Immunol,2001,166:6665.

同被引文献20

  • 1Carlsson B,Cheng WS,Totterman TH,et al.Ex vivo stimulation of cytomegalovirus (CMV)-specific T cells using CMV pp65-modified dendritic cells as stimulators[J].Br J Haematol,2003,121(3):428-438.
  • 2李艳萍 徐惠绵 徐小宁.MHC I类分子-肽-四聚体复合物研究CD8^+ T淋巴细胞.中国免疫学杂志,2004,21:105-108.
  • 3Altman JD,Moss PA,Goulder PJ,et al.Phenotypic analysis of antigen-specific T lymphocytes[J].Science,1996,274(5284):94-96.
  • 4Lang KS,Moris A,Gouttefangeas C,et al.High frequency of human cytomegalovirus (HCMV)-specific CD8^+ T cells detected in a healthy CMV-seropositive donor[J].Cell Mol Life Sci,2002,59(6):1076-1080.
  • 5Trojan A,Urosevic M,Hummerjohann J,et al.Immune reactivity against a novel HLA-A3-restricted influenza virus peptide identified by predictive algorithms and interferon-gamma quantitative PCR[J].J Immunother,2003,26(1):41-46.
  • 6Dunbar PR,Ogg GS,Chen J,et al.Direct isolation,phenotyping and cloning of low-frequency antigen specific cytotoxic T lymphocytes from peripheral blood[J].Curr Biol,1998,8(7):413-416.
  • 7Kalergis AM,Goyarts EC,Palmieri E,et al.A simplified procedure for the preparation of MHC/ peptide tetramers:chemical biotinylation of an un-paired cysteine engineered at the C-terminus of MHC I[J].J Immunol Methods,2000,234(1-2):61-70.
  • 8Xu XN,Screaton GR.MHC-peptide tetramer-based studies of T cell function[J].J Immunol Methods,2002,268(1):21-28.
  • 9Bras-Goncalves R,Le Gal FA,Avril MF,et al.In situ detection of antigen-specific tumor-infiltrating lymphocytes using newly designed tetramers[J].J Immunol Methods,2003,280(1-2):103-111.
  • 10Echchakir H,Dorothee G,Vergnon I,et al.Cytotoxic T lymphocytes directed against a tumor specific mutated antigen display similar HLA tetramer binding but distinct functional avidity and tissue distribution[J].Proc Natl Acad Sci USA,2002,99(14):9358-9363.

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上海免疫学杂志
2003年 第4期

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