阻塞性睡眠呼吸暂停患者白细胞抗原分型

Study on leukocyte antigen(HLA) type of patients with obstructive sleep apnea

目的 明确遗传因素在阻塞性睡眠呼吸暂停 (OSA)患者发病上的作用。方法 以中国北方 35例OSAS患者作为研究对象 ,北方汉族健康人群作为对照 ,采用聚合酶链反应 序列特异引物 (PCR SSP)分析的方法分析HLA A , B , DR抗原。结果 OSAS患者HLA A2 , B15 , DRB1 0 2 , DRB1 0 7及 DRB1 12抗原频率较对照组明显增高。结论 OSAS患者发病与HLA抗原特异性有关。

Objective To investigate the possible genetical influence on subjects with obstructive sleep spnea syndrome(OSAS). Methods Polymerase chain reaction-sequence specific primer(PCR-SSP)technique was used to analyse HLA-A, -B ,-DR antigens of 35 patients living in northern mandarine and with OSAS diagnosed by whole-night PSG. Results The frequency of HLA-A2,-B15,-DRB1*02,-DRB1*07,-DRB1*12 antigens were markedly increased in patients with OSAS compared with those in general population in northern China. Conclusion The specific HLA antigens might be relevant to the development of OSAS in patients living in northern mandarin China.