幽门螺杆菌毒力因子、宿主反应与相关胃肠疾病关系的研究进展

Research progression on association of Helicobacter pylori virulence,host response and related gastrointestinal diseases

幽门螺杆菌(HP)感染是上消化道疾病发展的潜在危险因素,但只有一小部分HP感染的患者会出现临床症状,HP感染所致相关胃肠疾病的严重程度,由HP毒力因子、宿主和环境因素相互作用决定。HP感染诱导的宿主细胞产生的免疫反应与HP毒力因子有关。HP感染后宿主防御反应的差异,极大的影响了HP感染后的临床后果,成为最新的研究热点。本文综述了HP毒力因子多态性、宿主反应差异对HP感染的临床后果的影响。

Helicobacter pylori(HP)infection is a potential risk factor for the development of gastroduodenal diseases.However,only a small percentage of infected people have clinical symptoms.The clinical outcomes caused by HP are associated with different bacteria virulence,environmental and host factors.Different host response induced by HP is related to different HP virulence genotypes.Different host defense to HP infection affect clinical outcomes greatly,which has become the hot issues in current research.This review focuses on the correlation between HP virulence,host response and related gastrointestinal diseases.