南疆地区维吾尔族与汉族肠癌患者胃肠道肿瘤标志物的表达差异

Differential expression of gastrointestinal tumor markers between Uygur and Han patients with intestinal cancer in southern Xinjiang

目的通过检测新疆维吾尔族(维族)、汉族肠癌患者血清胃肠肿瘤标志物的表达差异,为临床诊疗提供参考。方法选择237例肠癌患者,其中维族121例(男73例,女48例),汉族116例(男66例,女50例)。选587名体检健康者作为对照组,其中维吾尔族330例(男189例,女141例),汉族257例(男137例,女120例)。采用罗氏电化学发光法分别检测癌抗原125(CA125)、糖类抗原199(CA199)、糖类抗原72-4(CA72-4)、细胞角蛋白19片段(CY211)及癌胚抗原(CEA),比较南疆地区维吾尔族与汉族肠癌患者胃肠道肿瘤标志物的表达差异。结果肠癌患者中维族与汉族的血清CA199、CA72-4、CY211、CEA水平差异有统计学意义(P<0.05),血清CA125水平差异无统计学意义(P>0.05)。健康者中维族与汉族的血清CA125、CA199、CA72-4、CY211、CEA水平均差异无统计学意义(P>0.05)。维族肠癌患者血清CA125、CA199、CA72-4、CY211、CEA水平明显高于健康者,差异有统计学意义(P<0.05)。汉族肠癌患者血清CA125、CA199、CA72-4、CY211、CEA水平明显高于健康者,差异有统计学意义(P<0.05)。血清CA125在不同民族健康者和不同民族大肠癌患者中差异均无统计学意义(P>0.05)。结论维族与汉族肠癌患者血清CA199、CA72-4、CY211、CEA水平有明显差异,提示临床医师在应用血清标志物进行诊治与判断预后时要考虑民族因素。

Objective To detect the difference of serum gastrointestinal tumor markers in Xinjiang Uygur(Uygur)and Hanpatients with intestinal cancer,and provide reference for clinical diagnosis and treatment.Methods 237 patients withintestinal cancer were selected,including 121 Uygur(73 males and 48 females)and 116 Han(66 males and 50 females).587 healthy persons were selected as control group,including 330 Uygur(189 males and 141 females)and 257 Han(137 males and 120 females).Roche electrochemiluminescence was used to detect the expression of cancer antigen 125(CA125),carbohydrate antigen 199(CA199),carbohydrate antigen 72-4(CA72-4),cytokeratin 19 fragment(CY211)and carcinoembryonic antigen(CEA)in gastrointestinal cancer patients of Uygur and Han nationalities in southern Xinjiang.Results There were significant differences in serum CA199,CA72-4,CY211 and CEA levels between Uygur and Hannationalities(P<0.05),but no significant differences in serum CA125 levels between Uygur and Han nationalities(P>0.05).There were no significant differences in serum CA125,CA199,CA72-4,CY211 and CEA levels between Uygur andHan nationalities(P>0.05).The serum levels of CA125,CA199,CA72-4,CY211 and CEA in Uygur patients withintestinal cancer were significantly higher than those in healthy people(P<0.05).The serum levels of CA125,CA199,CA72-4,CY211 and CEA in patients with intestinal cancer of Han nationality were significantly higher than those in healthypeople(P<0.05).There was no difference in serum CA125 between healthy people of different nationalities and colorectalcancer patients of different nationalities(P>0.05).Conclusion There were significant differences in serum CA199,CA72-4,CY211 and CEA levels between Uygur and Han patients with intestinal cancer,suggesting that clinicians shouldconsider ethnic factors when using serum markers for diagnosis,treatment and prognosis.