急性心肌梗死病人血清可溶性细胞间粘附分子-1和补体C_3的动态变化

Changes in serum sICAM - 1 and complement C3 in patients with acute myocardial infarction.

目的:研究急性心肌梗死(AMI)病人血清可溶性细胞间粘附分子-1(sICAM-1)和补体C_3的动态变化。方法:采用免疫浊度法和ELISA法分别测定17例健康人(对照组)和17例AMI病人发病3、12、24、48、72、96小时血清sICAM-1和补体C_3水平。结果:(1)AMI发病3、12、24、48、72、96小时血清sICAM-1和补体C_3水平较对照组明显升高(P<0.05或P<0.01),AMI病人在上述时点sICAM-1水平在发病12小时即有显著升高(P<0.05),24小时达高峰,至发病96小时降至发病3小时水平,(2)AMI发病96小时内死亡者与存活者比较,发病3、12小时血清sICAM-1在死亡组均有更为显著的升高(P<0.05)。结论:sICAM-1和补体C_3参与了AMI发生、发展,且sICAM-1的测定可作为病情严重度和预后观察的一个指标。

Objective: To observe the changes in serum soluble intercellular adhesion molecule - l(sICAM - 1) and complement C3 in patients with acute myocardial infarction (AMI) . Methods: The levels of serum sICAM - 1 and complement C3 in 17 healthy subjects ( control group) and 17 patients with AMI were measured using ELISA or immunoturbidimetry. Results ; (1) The levels of serum sICAM - 1 and complement Ca in 17 patients with AMI were significantly higher than those in control group (P<0.05 or P<0.01).The levels of sICAM - 1 in those with AMI significantly became higher at 12th hour than those at 3rd hour after AMI (P<0.05) , and became highest at 24th hour after AMI (P<0.01) . After that , the levels of serum sICAM - 1 were becoming to be lower until the levels at 3rd hour after AMI . (2) During 96 hours after AMI , the levels of serum sICAM- 1 in the died were significantly higher than those in the survival at 3rd or 12th hour (P<0.05) . Conclusion: The complement C3 and ICAM - 1 participate the occurrence and development of AMI , and serum sICAM - 1 can be served as a clinical index of the seriousness of patients' condition and prognosis of AMI.