三种疗法治疗黄褐斑疗效观察

Observation of efficiency of three methods for treating chloasma.

目的:观察三种疗法对女性黄褐斑的疗效。方法:Ⅰ组中西医结合组100例,外用邦力迪维霜(0.1％维A酸霜)、3％氢醌霜,内服佳蓉片、维生素C、E。Ⅱ组西药组52例,外用邦力迪维霜、3％氢醌霜,内服维生素C、E。Ⅲ组外用药组86例,外用邦力迪维霜、3％氢醌霜。20天为一疗程,治疗1～3疗程。结果:显效率中Ⅰ组(78.0％)>Ⅱ组(61.5％)>Ⅲ组(54.7％),Ⅰ组与Ⅲ组比较(x^2=11.437,P<0.01),差异有显著性,Ⅰ组与Ⅱ组、Ⅱ组与Ⅲ组显效率差异无显著性(P>0.05)。结论:外用0.1％维A酸霜、3％氢醌霜,内服佳蓉片、维生素C、E治疗黄褐斑,有协同及标本兼治作用。

Objective:To observe the effect of three methods on female chloasma. Methods: In the group Ⅰ , 100 cases in the combined group with traditional Chinese and western medicine were treated with tretinoin cream and 3% ultraguin for external use,and with jiarong tablets, vitamin C and E for oral medication. In the group Ⅱ , 52 cases in the group with western medicine were treated with tretinoin cream, 3% ultraguin, vitamin C and E. In the group Ⅲ ,86 cases in the group were treated only with tretinoin cream and 3% ultraguin for external use. The course of treatment was 20 days, and 1 - 3 courses were required. Results: The notable effective rate of the group Ⅰ (78%) was larger than that of the group Ⅱ (61%), which was larger than that of group Ⅲ (54. 9% ). The difference between group Ⅰ and Ⅲ was significant (x2= 11. 437, P<0. 01), while that between group Ⅰ and Ⅱ and that between group Ⅱ and Ⅲ both were not obvious(P> 0.05) .Conclusion: The combined use of 0.025% tretinoin cream and 3% ultraguin for external use and jiarong tablets, vitamin C and E for oral medication for treating chloasma has effect in synergism as well as treating both the symptoms and cause at same time.