酪酸梭菌保留灌肠预防急性放射性直肠炎的临床观察

The Clinical Observation of Clostridium Butyric Acid Retention-enema in the Prevention of Acute Radiation Proctitis

目的观察酪酸梭菌保留灌肠预防宫颈癌急性放射性直肠炎的临床疗效。方法将60例宫颈癌患者随机分为联合组(30例)和单纯放疗组(30例)。两组均给予根治性放射治疗(体外照射+腔内治疗),联合组在放疗期间给予每周三次酪酸梭菌保留灌肠,睡前执行,单放组治疗期间仅给予常规放疗。结果联合组I度放射性直肠炎发生率为5/30,Ⅱ度放射性直肠炎的发生率为2/30,无Ⅲ度放射性直肠炎的发生,单放组I度放射性直肠炎的发生率为16/30,Ⅱ度放射性直肠炎的发生率为8/30,Ⅲ度放射性直肠炎的发生率为2/30,两组比较差异有统计学意义(P<0.0001)。结论酪酸梭菌保留灌肠是预防急性放射性直肠炎的有效方法。

Objective To observe the clinical efficacy of clostridium butyricum retention-enema to prevent acute radiation proctitis of cervical cancer. Methods 60 cervical cancer patients were randomly divided into combination group( 30 cases)and single radiotherapy group( 30 cases). All the patients received conventional radical radiation( extracorporeal irradiation and intracavitary therapy). The patients who are in combination group took clostridium butyricum retention-enema three times every-week before retiring while the other group just took radiotherapy alone during this time. Results Ⅰdegree of acute radiation proctitis incidence was 5 /30 in combination group,and that ofⅡgrade of acute radiation poctitis was 2 /30. There is no Ⅲdegree of acute radiation proctitis. In the single radiotherapy group,the incidence rates ofⅠ,Ⅱand Ⅲ grade of acute radiation poctitis were 16 /30,8 /30 and 2 /30. Comparing the two groups,the difference was statistically significant( P < 0. 0001). Conclusion Clostridium butyric acid retention enema is an effective method of prevention of acute radiation proctitis.