尼莫地平控制性降压对犬血流动力学的影响

Effects of Nimodipine on Hemodynamics during Deliberate Hypotension in Dogs

在健康杂种犬10只中,分别以15、30、45μg/kg 尼莫地平静注行控制性降压,监测平均动脉压和其它血流动力学指标。结果表明,15μg/kg、30μg/kg 和 45μg/kg 静注后,平均动脉压1min 时分别下降19.44％、29.93％和33.60％,45min 恢复对照水平。降压期间除心输出量指数、每搏量指数和总外周阻力指数外,其它各项指标无显著性改变。因此,我们认为尼莫地平可试用于临床控制性降压,其效果有待临床进一步观察。

Swan-Ganz catheter and NIHON-KOHDEN life scope 12 were used to monitor the hemodynamics effects of differentdosages nimodipine(15、30、45μg/kg) for deliberate hypotension in 10 dogs.The results showed that MAP decreased by19.44%、29.93% and 33.60% in one minute after 15μg/kg,30μg/kg,and 45μg/kg nimodipine were injected intravenouslyrespectively,and returned to control level in 45 minute.There were no significant changes on hemodynamies except Cl、SVIand SVRI during hypotension.Therefore,it is recommended that nimodipine should be tried as hypotensive agent.