止嗽散合三拗汤加减治疗急性气管-支气管炎风寒犯肺证临床研究

Clinical Study on Modified Zhike Powder Combined with San'ao Tang for Acute tracheobronchitis with Wind-cold Invading the Lung Syndrome

目的:观察止嗽散合三拗汤加减治疗急性气管-支气管炎风寒犯肺证的临床疗效。方法:将136例急性气管-支气管炎风寒犯肺证患者按随机数字表法分为对照组和观察组各68例。对照组口服小青龙合剂治疗,观察组采用止嗽散合三拗汤加减内服。观察治疗前后咳嗽症状积分、咳嗽视觉模拟评分(VAS)和风寒袭肺证评分,记录咳嗽转归情况。结果:观察组临床疗效总有效率为97.06%,高于对照组的82.29%(χ~2=5.849,P <0.05)。治疗后,2组咳嗽症状积分(日间、夜间)、VAS评分和风寒袭肺证评分较治疗前均显著降低(P <0.01);观察组嗽症状积分(日间、夜间)、VAS评分和风寒袭肺证评分均低于对照组(P <0.01)。观察组止咳起效时间、咳嗽缓解时间和咳嗽消失时间均短于对照组(P <0.05)。结论:止嗽散合三拗汤加减能显著改善急性气管-支气管炎风寒犯肺证咳嗽和中医证候,明显缩短了咳嗽病程,临床疗效显著。

Objective: To observe the clinical effect of modified Zhike powder combined with San’ao tang for acute tracheobronchitis with wind-cold invading the lung syndrome. Methods: Divided 136 cases of patients with acute tracheobronchitis with wind-cold invading the lung syndrome into the control group and the observation group according to random number table method, 68 cases in each group. The control group received Xiaoqinglong mixture orally for treatment,while the observation group received modified Zhike powder combined with San’ao tang orally. Observed the symptom score of cough, the score of visual analogue scale(VAS) of cough and the score of wind cold invading the lung syndrome before and after treatment, and recorded the outcome of cough. Results: The total effective rate was 97.06% in the observation group,higher than that of 82.29% in the control group(χ~2=5.849, P < 0.05). After treatment,the symptom score of cough at daytime and night, VAS score and the score of wind-cold invading the lung syndrome were significantly decreased in the two groups when compared with those before treatment(P < 0.01). The symptom score of cough at daytime and night, VAS score and the score of wind-cold invading the lung syndrome in the observation group were lower than those in the control group(P < 0.01).The onset time of relieving cough, the remission time of cough and the extinction time of cough in the observation group were shorter than those in the control group(P < 0.05). Conclusion: The therapy of modified Zhike powder combined with San’ao tang can obviously improve the cough and Chinese medicine syndrome of acute tracheobronchitis with wind-cold invading the lung syndrome,and obviously shorten the course of cough with significant clinical effect.