养胃消溃汤联合西药治疗难治性消化性溃疡临床研究

Clinical Study on Yangwei Xiaokui Tang Combined with Western Medicine for Refractory Peptic Ulcer

目的:观察养胃消溃汤联合西药治疗难治性消化性溃疡的临床疗效及对患者免疫功能、炎症因子的影响。方法:将80例患者按随机数字表法分为观察组42例和对照组38例,对照组采用奥美拉唑治疗,观察组在对照组的基础上联合养胃消溃汤治疗;治疗2周后,观察分析2组临床疗效、不良事件发生率及随访3月的复发率;检测比较2组患者治疗前后淋巴细胞CD8^+、CD4^+水平及炎症因子白细胞介素-6 (IL-6)、白细胞介素-2 (IL-2)和转化生长因子β1(TGF-β1)水平变化。结果:总有效率观察组为69.05%,对照组为47.37%,2组比较,差异有统计学意义(P <0.05)。治疗后,观察组CD8^+、CD4^+的含量均高于对照组,差异有统计学意义(P <0.05)。治疗后,观察组患者IL-2水平高于对照组,IL-6、TGF-β1水平低于对照组,差异均有统计学意义(P <0.05)。不良反应率、复发率观察组分别为11.90%、9.52%,对照组分别为36.84%、31.58%,2组比较,差异均有统计学意义(P <0.05)。结论:养胃消溃汤联合西药治疗难治性消化性溃疡,能够减轻患者炎症因子水平,改善患者的免疫功能,提高临床愈显率,疗效优于单纯西药治疗。

Objective: To observe the clinical effect of Yangwei Xiaokui tang combined with western medicine for refractory peptic ulcer and its effect on immune function and inflammatory factors of patients. Methods: Divided 80 cases of patients into the observation group and the control group randomly, 42 and 38 cases in each group respectively. The control group received omeprazole for treatment, while the observation group additionally received Yangwei Xiaokui tang based on the treatment of the observation group. After the two-week treatment, observed and analyzed the clinical effect, the incidence of adverse events and the recurrence rate during the three-month follow-up in the two groups. Detected and compared the levels of CD8+ and CD4+ of lymphocyte and the changes in levels of interleukins-6(IL-6), interleukins-2(IL-2)and transforming growth factor-β1 superfamily(TGF-β1) of inflammatory factors in the two groups before and after treatment.Results: The cured and markedly effective rate was 69.05% in the observation group and 47.37% in the control group, the difference being significant(P < 0.05). After treatment,the contents of CD8+ and CD4+ in the observation group were higher than those in the control group, the difference being significant(P < 0.05). After treatment,level of IL-2 in the observation group was higher than that in the control group, and levels of IL-6 and TGF-β1 were lower than those in the control group,differences being significant(P<0.05). The rate of adverse reactions and the recurrence rate were 11.90% and 9.52% in the observation group respectively,and 36.84% and 31.58% in the control group respectively,differences being significant(P <0.05). Conclusion: The therapy of Yangwei Xiaokui tang combined with western medicine for refractory peptic ulcer can relieve the inflammatory response,improve the immune function and increase the clinical cured and markedly effective rate,whose effect is better than that of the simple western medicine.