电针对脑微血管内皮细胞紧密连接调节作用研究进展

Research Progress on Electroacupuncture Regulating Tight Junction in Brain Microvessel Endothelial Cells

脑微血管内皮细胞(Brain microvessel endothelia cells,BMECs)间紧密连接(Tight junction,TJ)是血脑屏障(Blood-brain barrier,BBB)维持脑内外环境稳定的重要结构基础,同时,这一特殊结构也给许多中枢治疗药进入BBB带来一定的困难。电针作为临床治疗中枢神经疾病的重要手段,其对BBB通透性的影响尤其是对TJ的调节作用备受关注。本文综述了近10年电针对TJ的调节效应、调节机制的报道,为针药结合治疗中枢神经疾病提供一定的理论依据。

Tight junction(TJ) among brain microvessel endothelial cells(BMECs) is the essential structural basis of blood-brain barrier(BBB) for maintaining stability of the intracerebra and extracerebral environment, while this special structure also makes it relatively difficulty for many medicines for treating central nervous system diseases to enter BBB. As a significant method for clinically treating central nervous system diseases, the effect of electroacupuncture on the permeability of BBB, especially its regulatory effect on TJ, has drawn much attention. This article reviewed the reports of the regulatory effect of electroacupuncture on TJ and its regulation mechanism in recent 10 years,thus to provide some theoretical reference for the combined treatment of electroacupuncture and medicine for central nervous system diseases.