养心汤联合常规西药治疗心气虚弱型冠心病不稳定性心绞痛临床研究

Clinical Study on Yangxin Tang Combined with Conventional Western Medicine Therapy for Unstable Angina of Coronary Heart Disease of Heart Qi Weakness Type

目的:观察养心汤联合常规西药治疗心气虚弱型冠心病不稳定性心绞痛的临床疗效。方法:选取75例心气虚弱型冠心病不稳定性心绞痛患者为研究对象,按随机数字表法分为治疗组40例与对照组35例。对照组给予常规西药治疗,治疗组在常规西药基础上加用养心汤,2组均连续治疗4周。对比2组治疗前后血脂指标、中医症状评分、心电图的变化。结果:治疗前,2组甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)水平比较,差异均无统计学意义(P> 0.05)。治疗后,2组TG、TC、LDL-C水平均较治疗前降低(P <0.05),HDL-C水平均较治疗前上升(P <0.05);治疗组TG、TC、LDL-C水平均低于对照组(P <0.05),HDL-C水平高于对照组(P <0.05)。治疗前,2组心胸隐痛、心悸气短、失眠、易汗、乏力、倦怠懒言评分比较,差异均无统计学意义(P> 0.05)。治疗后,2组6项中医症状评分均较治疗前降低(P <0.05),治疗组6项中医症状评分均低于对照组(P <0.05)。治疗组心电图疗效总有效率97.50%,对照组心电图疗效总有效率77.14%,2组比较,差异有统计学意义(P <0.05)。结论:养心汤联合常规西药治疗心气虚弱型冠心病不稳定性心绞痛,可有效调节患者的血脂,改善临床症状,提高治疗效果。

Objective:To observe the clinical effect of Yangxin tang combined with conventional western medicine therapy for unstable angina of coronary heart disease of heart qi weakness type. Methods:A total of 75 patients with unstable angina of coronary heart disease of heart qi weakness type were enrolled as study subjects,and were divided into the treatment group(40 cases) and the control group(35 cases) according to the random number table method. The control group was given conventional western medicine therapy, while the treatment group was additionally given Yangxin tang based on the conventional western medicine therapy. The continuous treatment in both groups lasted for four weeks. The changes of blood lipid index,Chinese medicine symptom score and electrocardiogram before and after treatment in the two groups were compared. Results:There was no significant difference being found in the comparisons of the levels of triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(LDL-C) before treatment between the two groups(P > 0.05). After treatment,the levels of TG,TC and LDL-C in both groups were decreased when compared with those before treatment(P < 0.05),and the levels of HDL-C in both groups were increased when compared with those before treatment(P < 0.05);the levels of TG,TC and LDL-C in the treatment group were lower than those in the control group(P < 0.05),and the level of HDL-C in the treatment group was higher than that in the control group(P < 0.05).There was no significant difference being found in the comparison of the scores including dull pain in heart and chest,palpitation and shortness of breath,insomnia,easy to sweat,hypodynamia,burnout and dislike of talking before treatment between the two groups(P > 0.05). After treatment,six Chinese medicine symptom scores in both groups were decreased when compared with those before treatment(P < 0.05),and the six Chinese medicine symptom scores in the treatment group were lower than those in the control group(P < 0.05). The total effective rate of the curative effect of electrocardiogram was 97.5% in the treatment group and 77.14% in the control group,the difference being significant(P < 0.05). Conclusion:The therapy of Yangxin tang combined with conventional western medicine therapy for unstable angina of coronary heart disease of heart qi weakness type can effectively regulate the level of blood lipid of patients,improve clinical symptoms and enhance the clinical effect.