通络熄风汤治疗阴虚型缺血性脑卒中临床研究

Clinical Study on Tongluo Xifeng Tang for Ischemic Stroke of Yin-deficiency Type

目的:观察通络熄风汤联合西药治疗阴虚型缺血性脑卒中的临床疗效。方法:将88例阴虚型缺血性脑卒中患者按照入院顺序排序,根据奇偶数字法将其随机分为研究组和对照组,各44例;对照组采用西医常规治疗,研究组在对照组的基础上加用通络熄风汤治疗,2组均以10天为1疗程,共治疗2疗程,观察比较2组中医证候积分疗效、格拉斯哥-庇斯布赫昏迷分度表评分(G-PCS)、美国国立卫生院神经功能缺损评分(NIHSS),检测血清纤维蛋白原水平、同型半胱氨酸、β-内啡肽水平。结果:中医证候积分疗效总有效率研究组为88.64%,对照组为65.91%,2组比较,差异有统计学意义(P <0.05)。治疗前2组G-PCS、NIHSS评分无明显差异(P> 0.05);治疗后,研究组G-PCS评分明显高于对照组、NIHSS评分明显低于对照组,差异均有统计学意义(P <0.05)。治疗前,2组血清纤维蛋白原、同型半胱氨酸、血清β-内啡肽水平均处于一个较高水平,且组间比较,差异无统计学意义(P> 0.05);治疗后,研究组上述各项指标均明显低于对照组,差异有统计学意义(P <0.05)。结论:通络熄风汤联合西药治疗阴虚型缺血性脑卒中疗效显著,能显著改善患者神经功能和肢体活动功能,恢复血清学指标,促进病情康复。

Objective:To observe the clinical effect of Tongluo Xifeng tang combined with western medicine for ischemic stroke of yin-deficiency type. Methods:A total of 88 cases of patients with ischemic stroke of yin-deficiency type were divided into the study group and the control group by the odd-even number grouping method according to the order of admission,44 cases in each group. The control group was treated with routine western medicine,and the study group was additionally treated with Tongluo Xifeng tang based on the treatment of the control group. Both groups were treated with two courses,10 days being a course. The curative effect of Chinese medicine syndrome score,score of Glasgow-Pittsburgh coma scale(G-PCS),and score of National Institute of Health Stroke Scale(NIHSS) in both groups were observed and compared. The level of fibrinogen,homocysteine and β-endorphin in serum in both groups were detected. Results:The total effective rate of the curative effect of Chinese medicine syndrome score was 88.64% in the study group and 65.91% in the control group,the difference being significant(P < 0.05). Before treatment,no significant difference was found in the comparisons of the scores of G-PCS and NIHSS between the two groups(P > 0.05). After treatment,the score of G-PCS in the study group was obviously higher than that in the control group,and the score of NIHSS in the study group was obviously lower than that in the control group,differences being significant(P < 0.05). Before treatment,the levels of fibrinogen,homocysteine and β-endorphin in serum in the two groups were at a high level,and there was no significant difference being found between the two groups(P > 0.05). After treatment,the above indexes in the study group were obviously lower than those in the control group,the difference being significant(P < 0.05). Conclusion:The therapy of Tongluo Xifeng tang combined with western medicine has significant curative effect in treating ischemic stroke of yin-deficiency type,which can significantly improve the neurological function and the limb function,restore the serum index and promote the recovery of disease.