气滞胃痛胶囊辅助治疗上腹痛综合征临床研究

Clinical Study on Qizhi Weitong Capsules in Adjuvant Therapy of Epigastric Pain Syndrome

目的:观察气滞胃痛胶囊辅助治疗上腹痛综合征的临床疗效。方法:选取本院治疗的138例上腹痛综合征患者为研究对象,按照随机数字表法分为治疗组71例与对照组67例。对照组给予奥美拉唑肠溶胶囊和盐酸伊托必利片治疗,观察组在对照组基础上加用气滞胃痛胶囊。2组疗程均为4周。比较2组治疗效果,观察2组治疗前后汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评分、主症积分及血浆胃肠激素水平的变化。结果:治疗组总有效率87.32%,高于对照组的71.64%,差异有统计学意义(P <0.05)。治疗后,2组HAMD及HAMA评分均较治疗前降低(P <0.05);治疗组HAMD和HAMA评分均低于对照组(P <0.05)。治疗后,2组胃脘疼痛、胃脘嘈杂不适和腹满肠鸣积分均较治疗前降低(P <0.05);治疗组胃脘疼痛、胃脘嘈杂不适和腹满肠鸣积分均低于对照组(P <0.05)。治疗后,2组生长抑素水平均较治疗前降低(P <0.05),胃动素水平均较治疗前升高(P <0.05);治疗组生长抑素水平低于对照组(P <0.05),胃动素水平高于对照组(P <0.05)。结论:气滞胃痛胶囊辅助治疗上腹痛综合征疗效明显,可有效改善患者的焦虑、抑郁情绪,调节胃肠激素,值得临床借鉴。

Objective:To observe the clinical effect of Qizhi Weitong capsules in adjuvant therapy of epigastric pain syndrome. Methods:A total of 138 cases of patients with epigastric pain syndrome admitted into our hospital were selected as the study subjects,and were divided into the treatment group and the control group according to the random number table method,71 and 67 cases in each group respectively. The control group was given the oral administration of omeprazole enteric-coated capsules and itopride hydrochloride tablets,and the observation group was additionally given Qizhi Weitong capsules based on the treatment of the control group. The treatment of the two groups lasted for four weeks. The curative effect of the two groups were compared,and the changes of Hamilton depression scale scores(HAMD),Hamilton anxiety scale scores(HAMA),the score of main symptom and the level of gastrointestinal hormones in plasma were observed.Results:The total effective rate was 87.32% in the treatment group,higher than that of 71.64% in the control group,the difference being significant(P < 0.05). After treatment,the HAMD and HAMA scores in the two groups were decreased compared with those before treatment(P < 0.05);the HAMD and HAMA scores in the treatment group were lower than those in the control group(P < 0.05). After treatment,the scores of epigastric pain,epigastric noisiness and discomfort,and abdominal fullness and borborygmus in the two groups were decreased compared with those before treatment(P < 0.05). After treatment,the scores of epigastric pain,epigastric noisiness and discomfort,and abdominal fullness and borborygmus in the treatment groups were lower than those in the control group(P < 0.05). After treatment,the levels of somatostatin in the two groups were decreased compared with those before treatment(P < 0.05). The level of motilin in the two groups were increased compared with those before treatment(P < 0.05). The level of somatostatin in the treatment group was lower than that in the control group(P < 0.05),and the level of motilin in the treatment group was higher than that in the control group(P < 0.05). Conclusion:The clinical effect of Qizhi Weitong capsules in adjuvant therapy of epigastric pain syndrome is significant and the anxiety and depression of patients can be effectively improve and the level of motilin can be adjusted,which is worthy of clinical reference.