壮骨关节胶囊与复方伤痛胶囊分别配伍玻璃酸钠治疗创伤性膝关节炎疗效差异性分析

Difference Analysis of the Curative Effect of Zhuanggu Guanjie Capsules and Compound Shangtong Capsules Respectively with Compatibility of Sodium Hyaluronate for Traumatic Knee Arthritis

目的:观察壮骨关节胶囊与复方伤痛胶囊分别配伍玻璃酸钠治疗创伤性膝关节炎的疗效差异性。方法:选取创伤性膝关节炎患者110例作为研究对象,按随机数字表法均分为观察组和对照组各55例。对照组采用复方伤痛胶囊联合关节腔内注射玻璃酸钠治疗;观察组采用壮骨关节胶囊联合关节腔内注射玻璃酸钠治疗。观察并比较2组临床疗效、膝关节评分(HSS)评分、关节活动度、日常生活活动能力(ADL)评分及不良反应情况。结果:观察组总有效率为92.73%,高于对照组的87.27%,2组比较,差异无统计学意义(P> 0.05)。2组治疗后2组HSS评分、关节活动度、ADL评分均较前改善(P <0.05)。治疗前、治疗后2组间HSS评分、关节活动度、ADL评分比较,差异均无统计学意义(P> 0.05)。观察组不良反应率为14.55%(8/55),对照组不良反应率为3.64%(2/55),组间比较,差异有统计学意义(P=0.047 <0.05)。结论:壮骨关节胶囊与复方伤痛胶囊分别配伍玻璃酸钠治疗创伤性膝关节炎的疗效差异性不大,都能明显改善患者膝关节功能,提高日常独立活动能力,是可行的保守治疗方案,但复方伤痛胶囊配伍玻璃酸钠治疗的安全性相对高。

Objective:To observe the d ifference of the curative effect of Zhuanggu Guanjie capsules and compound Shangtong capsules respectively with compatibility of sodium hyaluronate for traumatic knee arthritis. Methods:Selected 110 cases of patients with traumatic knee arthritis as study subjects,and divided them into the observation group and the control group according to the random number table method,55 cases in each group. The control group was given compound Shangtong capsules combined with intra-articular injection of sodium hyaluronate,while the observation group was given Zhuanggu Guanjie capsules combined with intra-articular injection of sodium hyaluronate for treatment. Observed and compared the clinical effect,hospital for special surgery knee score(HSS),range of motion,scores of activities of daily living(ADL) and the adverse reactions. Results:The total effective rate was 92.73% in the observation group,higher than of 87.27% in the control group,there being no significance in the difference(P > 0.05). After treatment,the HSS,range of motion and scores of ADL in the two groups were all improved(P < 0.05). There was no significant difference being found in the comparisons of the HSS,range of motion and scores of ADL before and after treatment in the two groups(P > 0.05). The incidence of adverse reaction was 14.55%(8/55) in the observation group and 3.64%(2/55) in the control group,the difference being significance(P=0.047 < 0.05). Conclusion:The difference of the curative effect of Zhuanggu Guanjie capsules and compound Shangtong capsules respectively with compatibility of sodium hyaluronate for traumatic knee arthritis is little.However,as a practical conservative therapy,it can improve the knee joint function and the activities of daily living of patients,and the safety of the compatibility of compound Shangtong capsules and sodium hyaluronate is relatively higher.