温经汤联合地屈孕酮治疗黄体功能不全致不孕不育临床研究

Clinical Study on Wenjing Tang Combined with Dydrogesterone for Infertility Caused by Luteal Phase Defect

目的:观察温经汤联合地屈孕酮治疗黄体功能不全导致的不孕不育的临床疗效。方法:将因黄体功能不全所导致不孕不育患者42例根据患者在治疗时所采取的治疗方式不同分为2组各21例。对照组单纯采用地屈孕酮治疗,观察组采用温经汤联合地屈孕酮治疗,观察2组治疗前后的孕酮水平、血清雌二醇水平以及子宫内膜厚度,观察2组妊娠情况。结果:治疗前,2组孕酮水平和血清雌二醇水平比较,差异无统计学意义(P> 0.05)。治疗后,2组孕酮水平和血清雌二醇水平都增高(P <0.05),且观察组明显高于对照组(P <0.05)。治疗前,2组子宫内膜厚度比较,差异无统计学意义(P> 0.05);治疗后,2组内膜明显增厚(P <0.05),且观察组治疗后内膜厚度与对照组比较,差异有统计学意义(P <0.05)。观察组妊娠率为85.71%(18/21),对照组妊娠率为47.62%(10/21),2组比较,差异有统计学意义(P <0.05)。结论:应用温经汤联合地屈孕酮治疗黄体功能不全所导致的不孕不育可增强其临床治疗效果,提高患者的妊娠率。

Objective:To observe the clinical effect of Wenjing tang combined with dydrogesterone for infertility caused by luteal phase defect.Methods:A total of 42 cases of patients with infertility caused by luteal phase defect were divided into two groups according to the different treatment modalities adopted by the patients,21 cases in each group.The control group was treated with dydrogesterone only,while the observation group was given the therapy of Wenjing tang combined with dydrogesterone.The levels of progesterone and serum estradiol as well as the endometrial thickness in the two groups were observed before and after treatment;pregnancy in the two groups were observed.Results:There was no significant difference being found in the comparisons of the levels of progesterone and serum estradiol between the two groups before treatment(P>0.05).After treatment,the levels of progesterone and serum estradiol were increased in both groups(P<0.05),and the improvement in the observation group was significantly higher than that in the control group(P<0.05).There was no significant difference being found in the comparison of the endometrial thickness between the two groups before treatment(P>0.05);after treatment,the endometrial thickness was increased in the two groups(P<0.05).Compared the endometrial thickness in the two groups after treatment,the difference being significant(P<0.05).The pregnancy rate was 85.71%(18/21)in the observation group and 47.62%(10/21)in the control group,the difference being significant(P<0.05).Conclusion:The therapy of Wenjing tang combined with dydrogesterone for infertility caused by luteal phase defect can improve the clinical effect,and increase the pregnancy rate of patients.