补肾健脾利水法治疗慢性肾功能不全临床研究

Clinical Study on Method of Supplementing the Kidney, Fortifying the Spleen and Promoting Urination for Chronic Renal Insufficiency

目的:观察补肾健脾利水法应用于慢性肾功能不全治疗中的临床疗效。方法:将100例诊断为慢性肾功能不全患者分为2组各50例。对照组给予炭片、尿毒清颗粒及大黄碳酸氢钠治疗;治疗组在对照组治疗基础上采用补肾健脾利水法治疗。治疗2月后评价2组临床疗效,并检测2组患者治疗前后24 h尿蛋白定量和血肌酐及谷丙转氨酶水平,记录治疗期间不良反应。结果:治疗组总有效率为90.0%,对照组为60.0%,2组比较,差异有统计学意义(P <0.05)。治疗前,2组24 h尿蛋白定量、血肌酐、谷丙转氨酶水平比较,差异无统计学意义(P> 0.05)。治疗后,2组24 h尿蛋白定量、血肌酐水平较治疗前下降(P <0.05),而治疗组下降程度更显著(P <0.05);2组治疗后谷丙转氨酶水平升高(P <0.05),对照组升高更显著(P <0.05)。2组不良反应率比较,差异无统计学意义(χ2=0.153,P=0.695)。结论:补肾健脾利水法用于临床治疗慢性肾功能不全效果显著、安全。

Objective:To observe the clinical effect of the method of supplementing the kidney,fortifying the spleen and promoting urination for chronic renal insufficiency.Methods:A total of 100 cases of patients diagnosed with chronic renal insufficiency were divided into two groups,50 cases in each group.The control group was given carbon pile,Niaoduqing granules as well as rhubarb and sodium bicarbonate tablets,while the treatment group was additionally treated with the method of supplementing the kidney,fortifying the spleen and promoting urination based on the treatment of the control group.After two-month treatment,the clinical effect in the two groups was evaluated;the 24-hour urine protein,the levels of serum creatinine and alanine aminotransferase in the two groups were monitored before and after treatment,and the adverse reactions during the treatment period were recorded.Results:The total effective rate was 90.0%in the treatment group and 60.0%in the control group,the difference being significant(P<0.05).There was no significant difference being found in the comparisons of the 24-hour urine protein,the levels of serum creatinine and alanine aminotransferase in the two groups before treatment(P>0.05).After treatment,the 24-hour urine protein and the levels of serum creatinine in the two groups were decreased when compared with those before treatment(P<0.05),and the decrease in the treatment group was more obvious than that in the control group(P<0.05);the levels of alanine aminotransferase in the two groups were increased when compared with those before treatment(P<0.05),and the increase in the control group was more obvious than that in the treatment group(P<0.05).There was no significant difference being found in the comparison of adverse reactions rate between the two groups(χ2=0.153,P=0.695).Conclusion:The method of supplementing the kidney,fortifying the spleen and promoting urination has significant clinical effect on chronic renal insufficiency with safety.