丹红注射液联合唑来膦酸治疗胸腰椎骨折术后疗效观察及对血清骨代谢指标的影响

Clinical Observation of Curative Effect of Danhong Injection Combined with Zoledronic Acid for Postoperative Thoracolumbar Fracture and Its Effect on Serum Bone Metabolism Indexes

目的:探讨丹红注射液联合唑来膦酸治疗胸腰椎骨折术后的临床疗效及对血清骨代谢指标的影响。方法:将行胸腰椎骨折术患者120例随机分为实验组与对照组,各60例;对照组术后给予唑来膦酸治疗,实验组术后给予丹红注射液联合唑来膦酸治疗,2组均治疗30天,观测2组骨钙素(BGP)、骨碱性磷酸酶(BALP)、Ⅰ型前胶原羧基端肽(PICP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)、总前Ⅰ型前胶原氨基端延长肽(T-PINP)等骨代谢指标水平、骨密度及Cobb角变化,并比较2组临床疗效。结果:总有效率实验组为96.67%,对照组为75.00%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组血清BGP、BALP、PICP水平较治疗前升高(P <0.05),β-CTX、T-PINP水平较治疗前下降(P <0.05);且实验组上述各项指标改善较对照组更显著(P <0.05)。治疗后,2组BMD值均较治疗前增高(P <0.05);且实验组BMD值明显高于对照组(P <0.05)。治疗后2组Cobb角均较治疗前缩小(P <0.05);且实验组Cobb角明显小于对照组(P <0.05)。结论:丹红注射液联合唑来膦酸治疗胸腰椎骨折术后患者疗效显著,可有效调节患者骨性标志物水平,促进骨密度增加,改善Cobb角,值得临床推广应用。

Objective:To discuss the clinical effect of Danhong injection combined with zoledronic acid for postoperative thoracolumbar fractures and its effect on serum bone metabolism indexes.Methods:Divided 120 cases of patients with thoracolumbar fractures randomly into the experiment group and the control group,60 cases in each group.The control group was treated with zoledronic acid,and the experiment group was treated with Danhong injection combined with zoledronic acid.The two groups were both treated for 30 days.Observed the levels of bone metabolic indexes such as osteocalcin(BGP),bone alkaline phosphatase(BALP),type I procollagen carboxy terminal peptide(PICP),type I collagen carboxy terminal peptideβspecial sequence(β-CTX),total pre-type I terminal prolongation peptide(T-PINP)in the two groups,bone mineral density and the changes of Cobb angle,and compared the clinical effect in the two groups.Results:The total effective rate was96.67%in the experiment group and 75.00%in the control group,compared the two groups,difference being significant(P<0.05).After treatment,the levels of serum BGP,BALP and PICP in the two groups were increased when compared with those before treatment(P<0.05);the levels ofβ-CTX and T-PINP were decreased when compared with those before treatment(P<0.05);the improvement of these indexes mentioned above in the experiment group was more significant than that in the control group(P<0.05).After treatment,the BMD values of the two groups were increased when compared with those before treatment(P<0.05);and the BMD value of the experiment group was significantly higher than that of the control group(P<0.05).After treatment,the Cobb angles of the two groups were smaller than those before treatment(P<0.05);the Cobb angle of the experiment group was evidently smaller than that of the control group(P<0.05).Conclusion:Theapplication of Danhong injection combined with zoledronic acid has obvious curative effect in treating postoperative thoracolumbar fractures in patients.It can effectively regulate the level of bony landmarks,promote bone density,and improve the Cobb angle.It is worthy of clinical promotion and application.