四黄散联合微波治疗Ⅲ期褥疮临床研究

Clinical Study on Sihuang Powder Combined with Microwave for Bedsores at Stage III

目的:观察四黄散联合微波治疗Ⅲ期褥疮的临床疗效及对肿瘤坏死因子-α(TNF-α)、白细胞介素-6 (IL-6)的影响。方法:将Ⅲ期褥疮患者36例按入院时间顺序随机分为观察组和对照组,各18例。对照组患者给予常规消毒治疗,观察组患者褥疮局部给予四黄散外用联合微波每天治疗20 min,治疗7天后观察比较2组临床疗效,并于治疗第3、7天检测2组患者血清TNF-α、IL-6的水平变化。结果:总有效率观察组为100%,对照组为61.11%,2组比较,差异有统计学意义(P <0.05)。治疗后第3、7天,2组患者TNF-α、IL-6水平均较治疗前明显下降(P <0.05);且观察组TNF-α、IL-6水平下降较对照组同时间段更显著(P <0.05)。结论:四黄散联合微波治疗能减轻Ⅲ期褥疮患者的炎症反应,利于褥疮修复,临床疗效良好。

Objective:To observe the clinical effect of Sihuang powder combined with microwave for bedsores at stage III as well as its effect on tumor necrosis factor alpha(TNF-α)and interleukin-6(IL-6).Methods:A total of 36 cases of patients with bedsores at stage III were randomly divided into the observation group and the control group according to the order of admission,18 cases in each group.The control group was treated with routine disinfection,while the observation group was treated with Sihuang powder combined with microwave for 20 min daily.The clinical effect in the two groups were observed and compared after seven days of treatment,and the changes in the levels of serum TNF-αand IL-6 in the two groups were detected on the 3 rdand 7 thday after treatment.Results:The total effective rate was 100%in the observation group and61.11%in the control group,the difference being significant(P<0.05).On the 3 rdand 7 thday after treatment,the levels of TNF-αand IL-6 in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the decrease in the observation group was more significant than that in the control group in the same period(P<0.05).Conclusion:The therapy of Sihuang powder combined with microwave can reduce inflammatory responses of patients with bedsores at stage III,which is beneficial to the restoration of bedsores with good clinical effect.