T2DM患者中医证候辨证规律及与血生化指标相关性分析

Correlation Analysis of the Law of Syndrome Differentiation of Chinese Medicine Syndrome and Blood Biochemical Indexes in Patients with T2DM

目的:分析2型糖尿病(T2DM)患者正虚血浊证候辨证规律与血生化指标的相关性,为治疗T2DM提供理论依据。方法:选取128例辨证为正虚血浊证2型糖尿患者为研究对象,对各个症状进行量化处理,分为四个层级:无、轻、中和重,分别赋值0、1、3和5分,记录患者血浊证得分,使用全自动血液细胞分析仪对患者血液进行分析,记录患者姓名、年龄、身高等基本信息,检测患者正虚血浊分型及血生化指标[葡萄糖(Glu)、红细胞压积(PCV)、血小板压积(PCT)、甘油三酯(TG)、同型半胱氨酸(Hcy)]水平,并分析其中相关性。结果:血浊积分与T2DM患者BMI、病程和年龄均呈正相关(P <0.05),与并发症无明显相关。T2DM患者正虚血浊类型中气虚血浊证患者最多,为91例,占比71.09%;阳虚血浊患者最少,为6例,占比为4.69%。患者血浊积分与PCT、TG和Hcy均呈正相关(P <0.05),且与Hcy相关性最大。T2DM患者各正虚血浊类型中,阴虚血浊证与PCT、Hcy呈正相关(P <0.05),与Glu、PCV呈负相关(P <0.05);阳虚血浊证、气虚血浊证均与TG、Hcy呈正相关(P<0.05),与Glu、PCV呈负相关(P <0.05);血虚血浊证与PCT、TG、Hcy呈正相关(P <0.05),与PCV呈负相关(P <0.05)。结论:T2DM患者正虚血浊证与患者Glu、PCV、PCT、TG和Hcy等指标密切相关,通过对患者血生化学指标的检测可为T2DM辨证治疗提供参考依据。

Objective:To analyze the correlation between the law of syndrome differentiation and the blood biochemical indexes in patients with type 2 diabetes mellitus(T2 DM)with different typing of syndrome of vital qi deficiency and blood turbidity,so as to provide theoretical basis for the treatment of T2 DM.Methods:A total of 128 cases of patients with T2 DM who were differentiated with syndrome of vital qi deficiency and blood turbidity were selected as the study subjects.Each symptom was given the quantitative disposal which was divided into four hierarchies,including none,mildness,medium and severity,with 0,1,3 and 5 points respectively.The score of syndrome of blood turbidity was recorded.The blood of patients was analyzed by automated hematology analyzer.The basic information of patients including name,age and height was observed and recorded.The typing of vital qi deficiency and blood turbidity as well as the blood biochemical indexes,including the levels of glucose(Glu),packed cell volume(PCV),plateletcrit(PCT),triglyceride(TG)and homocysteine(Hcy),were recorded in detail and the correlation between them was analyzed.Results:The score of blood turbidity was positively correlated with BMI,course of disease and age of patients with T2 DM(P<0.05),with no significant correlation with complications.The score of blood turbidity of patients with T2 DM was positively correlated with PCT,TG and Hcy(P<0.05),and its correlation with Hcy was the highest.Among each type of vital qi deficiency and blood turbidity of patients with T2 DM,the syndrome of yin deficiency and blood turbidity had a positive correlation with PCT and Hcy(P<0.05),while had a negative correlation with Glu and PCV(P<0.05).Both the syndrome of yang deficiency and blood turbidity and the syndrome of qi deficiency and blood turbidity had a positive correlation with TG and Hcy(P<0.05),while had a negative correlation with Glu and PCV(P<0.05).The syndrome of blood deficiency and blood turbidity had a positive correlation with PCT,TG and Hcy(P<0.05),while had a negative correlation with PCV(P<0.05).Conclusion:The syndrome of vital qi deficiency and blood turbidity in patients with T2 DM has a close correlation with Glu,PCV,PCT,TG and Hcy.The detection of the blood biochemical indexes of patients can provide a reference for T2 DM by syndrome differentiation and treatment.