四磨汤联合常规西医治疗肝脾不和型功能性消化不良临床研究

Clinical Study on Simo Tang Combined with Routine Western Medicine for Functional Dyspepsia of Liver-Spleen Disharmony Type

目的:研究四磨汤联合常规西医治疗肝脾不和型功能性消化不良的临床疗效及对患者胃肠功能的影响。方法:选择90例肝脾不和型功能性消化不良患者为研究对象,按随机数字表法分为观察组和对照组各45例。对照组采用常规西医疗法治疗,观察组在对照组基础上增加四磨汤内服治疗。2组患者连续治疗3个月后评估对比临床疗效,并对2组患者中医证候积分、胃肠功能、用药安全性等进行评价比较。结果:观察组总有效率为91.11%,高于对照组73.33%,差异有统计学意义(P <0.05)。治疗后,2组中医证候积分包括脘腹胀痛、呃逆、大便不畅等评分均较治疗前降低(P <0.05),且观察组中医证候积分包括脘腹胀痛、呃逆、大便不畅等评分均低于对照组(P <0.05)。治疗后,2组胃排空率、胃动素、P物质水平较治疗前升高,胆囊收缩素(CCK)较治疗前降低,差异均有统计学意义(P <0.05)。治疗后,观察组胃排空率、胃动素、P物质水平均高于对照组,CCK水平低于对照组,差异均有统计学意义(P <0.05)。观察组不良反应发生率为13.33%,对照组为8.89%,2组比较,差异无统计学意义(P>0.05)。结论:四磨汤联合常规西医治疗肝脾不和型功能性消化不良的临床疗效显著,能够改善患者的中医证候积分和胃肠功能,用药安全性良好,可以在临床上推广应用。

Objective:To study the clinical effect of Simo tang combined with routine western medicine for functional dyspepsia of liver-spleen disharmony type and its effect on the gastrointestinal function of patients.Methods:A total of 90 cases of patients with functional dyspepsia of liver-spleen disharmony type selected as the research subjects were divided into the observation group and the control group according to the random number table method,45 cases in each group.The control group was given routine western medicine for treatment,while the observation group was additionally given Simo tang based on the treatment of the control group.After the two groups were continuously treated for three months,the clinical effect of the two groups was compared.The scores of Chinese medicine syndrome,gastrointestinal function,and drug safety in the two groups were evaluated and compared.Results:The total effective rate was 91.11%in the observation group,being higher than that of 73.33%in the control group,difference being significant(P<0.05).After treatment,the scores of Chinese medicine syndrome such as the scores of abdominal distension,hiccup and reluctant bowel movements in the two groups were decreased when compared with those before treatment(P<0.05);the scores of Chinese medicine syndrome such as the scores of abdominal distension,hiccup and reluctant bowel movements in the observation group were lower than those in the control group(P<0.05).After treatment,the gastric emptying rate,motilin and the level of substance P were increased when compared with those before treatment;the level of cholecystokinin(CCK)was decreased when compared with that before treatment,differences being significant(P<0.05).After treatment,the gastric emptying rate,motilin and the level of substance P in the observation group were higher than those in the control group;the level of CCK was lower than that in the control group,differences being significant(P<0.05).The occurrence rate of adverse reaction was 13.3%in the observation group and was 8.89%in the control group,there being no significance in the difference(P>0.05).Conclusion:The application of Simo tang combined with routine western medicine has obvious clinical effect in treating functional dyspepsia of liver-spleen disharmony type,which can improve the scores of Chinese medicine syndrome and the gastrointestinal function.It has good drug safety and can be clinically promoted and adopted.