生脉真武救心汤对心衰患者氧化应激状态影响的研究

Study on the Effect of Shengmai Zhenwu Jiuxin Tang on Oxidative Stress Status in Patients with Heart Failure

目的:观察生脉真武救心汤对心力衰竭患者氧化应激状态的影响。方法:采用随机平行对照方法纳入98例心衰患者为研究对象,随机分为2组各49例。对照组予以常规西医治疗,观察组在对照组治疗方案的基础上予以生脉真武救心汤治疗。以治疗8周为1个疗程,均持续治疗1个疗程。比较2组中医证候疗效,观察治疗前后天门冬氨酸氨基转移酶(AST)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、羟丁酸脱氢酶(HDBH)水平,并分析氧化应激指标谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平。结果:总有效率观察组91.84%,对照组75.51%,2组比较,差异有统计学意义(P <0.05)。治疗后,观察组AST、CK、CK-MB、LDH、HDBH、MDA水平均低于治疗前,GSH-Px、CAT、SOD水平高于治疗前,前后比较,差异均有统计学意义(P <0.05);2组间AST、CK、CK-MB、LDH、HDBH、MDA、GSH-Px、CAT、SOD比较,差异均有统计学意义(P <0.05)。结论:生脉真武救心汤治疗心衰疗效显著,能有效降低心肌酶谱水平,改善氧化应激状态。

Objective:To observe the effect of Shengmai Zhenwu Jiuxin tang on oxidative stress status in patients with heart failure.Methods:A total of 98 cases of patients with heart failure were enrolled as the study subjects according to the random parallel control method,and were randomly divided into two groups,49 cases in each group.The control group was given the routine western medicine for treatment,and the observation group was additionally given Shengmai Zhenwu Jiuxin tang based on the treatment of the control group.The two groups continuously received the treatment for one week,eight weeks being a course.The curative effect of the Chinese medicine syndrome in the two groups was compared.The levels of aspartate aminotransferase(AST),creatine kinase(CK),creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH),hydroxybutyrate dehydrogenase(HBDH)before and after treatment were observed and the oxidative stress indexes including the levels of glutathione peroxidase(GSH-Px),catalase(GAT),superoxide dismutase(SOD)and Malonic dialdehyde(MDA)were analyzed.Results:The total effective rate was 91.84%in the observation group and 75.51%in the control group,the difference being significant(P<0.05).After treatment,the levels of AST,CK,CK-MB,LDH,HDBH and MDA in the observation group were decreased when compared with those before treatment,and the levels of GSH-Px,CAT and SOD were increased when compared with those before treatment,differences being significant(P<0.05).Compared with the levels of AST,CK,CK-MB,LDH,HDBH,MDA,GSH-Px,CAT and SOD between the two groups,differences being significant(P<0.05).Conclusion:The therapy of Shengmai Zhenwu Jiuxin tang for heart failure has significant curative effect,which can effectively decrease the level of myocardial enzymes and improve the oxidative stress status.