丹参注射液联合甲基泼尼松龙治疗重症肺炎支原体肺炎临床研究

Clinical Study on Danshen Injection Combined with Methylprednisolone for Severe Mycoplasma Pneumonia

目的:观察丹参注射液联合甲基泼尼松龙治疗重症肺炎支原体肺炎的疗效及安全性。方法:将60例重症肺炎支原体肺炎患者按随机数字表法分为2组各30例。对照组给予阿奇霉素、甲基泼尼松龙治疗;观察组在对照组基础上加用丹参注射液,序贯治疗,2组治疗时间均为2个疗程;评价2组患者的退热时间、咳嗽好转时间、啰音明显好转时间、肺部X线改变好转时间与住院时间等临床症状改善情况,测定2组患者治疗前后血清降钙素原(PCT)与C-反应蛋白(CRP)水平;观察并统计疗程内不良反应发生情况。结果:总有效率观察组为86.67%,对照组为66.67%,2组比较,差异有统计学意义(P <0.05)。观察组退热时间、咳嗽好转时间、啰音明显好转时间、肺部X线改变好转时间与住院时间低于对照组,2组比较,差异有统计学意义(P <0.05)。2组患者治疗前PCT与CRP水平比较,差异无统计学意义(P> 0.05)。治疗后,2组PCT与CRP水平较前改善(P <0.05)。2组治疗后PCT与CRP水平比较,差异有统计学意义(P <0.05)。治疗过程中,2组患者均未出现与用药相关的不良反应情况。结论:甲基泼尼松龙联合丹参注射液治疗重症肺炎支原体肺炎患者,疗效显著,且安全性较好。

Objective:To observe the curative effect and safety of Danshen injection combined with methylprednisolone for severe mycoplasma pneumonia.Methods:A total of 60 cases of patients with severe mycoplasma pneumonia were divided into two groups according to the random number table method,30 cases in each group.The control group was given azithromycin and methylprednisolone for treatment,and the observation group was additionally given Danshen injection and sequential therapy based on the treatment of the control group.The treatment lasted for two courses.The improvement of the clinical symptoms in the two groups were evaluated including the fever subsidence time,the improvement time of cough,the significant improvement time of rale,the improvement time of changes of chest X-ray and the hospitalization time.The level of procalitonin(PCT)and the level of C-reactive protein(CRP)in serum before and after treatment were measured.The occurrence of the adverse reactions was observed and calculated during the course of treatment.Results:The total effective rate was 86.67%in the observation group and was 66.67%in the control group,the difference being significant(P<0.05).The fever subsidence time,the improvement time of cough,the significant improvement time of rale,the improvement time of changes of chest X-ray and the hospitalization time in the observation group were lower than those in the control group,the difference being significant(P<0.05).No significant difference was found in the comparison of the levels of PCT and CRP between the two groups with those before treatment(P>0.05).After treatment,the levels of PCT and CRP in the two groups were improved when compared with those before treatment(P<0.05).The comparisons of the levels of PCT and CRP between the two groups showed significance in the differences(P<0.05).During the treatment,no adverse reactions related to medication occurred in neither group.Conclusion:The therapy of Danshen injection combined with methylprednisolone has significant curative effect and good safety in treating patients with severe mycoplasma pneumonia.