养阴活血方对胃癌前病变肠道菌群变化及转归的影响

Yangyin Huoxue Prescription Has Effect on Intestinal Flora Changes and Prognosis of Gastric Precancerous Lesions

目的:观察养阴活血方对胃癌前病变肠道菌群变化及转归的影响。方法:将66例胃癌前病变患者分为2组各33例。对照组为口服四联给药方案,治疗组在对照组基础上加用养阴活血方,通过比较临床疗效,胃黏膜组织病理检测及肠道菌群(乳酸杆菌、大肠杆菌、双歧杆菌)数量进行疗效评定。结果:治疗组总有效率为87.88%,优于对照组总有效率66.67%,经秩和检验,差异有统计学意义(P <0.05)。经治疗,治疗组提高患者肠道菌群中乳酸杆菌、双歧杆菌,降低大肠杆菌,与治疗前比较,差异有统计学意义(P <0.05)。治疗组治疗后乳酸杆菌、大肠杆菌、双歧杆菌与对照组比较,差异有统计学意义(P <0.05)。治疗后,治疗组胃镜下黏膜病变积分大体分级、部分分级均较治疗前改善(P <0.05),且治疗组治疗后2个分级积分与对照组比较,差异均有统计学意义(P <0.05)。结论:养阴活血方能调控胃癌前病变患者肠道菌群平衡,改善胃黏膜病理变化,有益于胃癌前病变的转归。

Objective:To observe the effect of Yangyin Huoxue prescription on intestinal flora changes and prognosis of gastric precancerous lesions.Methods:Divided 66 cases of patients with precancerous lesions into two groups,33 cases in each group.The control group was treated with the oral application of four combined drug administration,while the treatment group was additionally given with Yangyin Huoxue prescription.Evaluated the curative effect by comparing the clinical effect,pathological examination of gastric mucosa and the number of intestinal flora(lactobacillus,escherichia coli,bifidobacterium).Results:The total effective rate was87.88%in the treatment group,being higher than that of 66.67%in the control group,difference being significant(P<0.05).After treatment,lactobacillus and bifidobacteria of the intestinal flora in the treatment group were increased and escherichia coli was decreased,compared with those before treatment,difference being significant(P<0.05).After treatment,there was significant difference being found in the comparison between the lactobacillus,escherichia coli and bifidobacterium in the treatment group and that in the control group,difference being significant(P<0.05).After treatment,the general classification and partial classification of the gastroscopic mucosal lesion scores in the treatment group were improved when compared with those before treatment(P<0.05);there was significant difference being found in the comparison between the score of these two classifications in the treatment group and that in the control group,difference being significant(P<0.05).Conclusion:The application of Yangyin Huoxue prescription can regulate the balance of intestinal flora in patients with precancerous lesions and improve the pathological changes of gastric mucosa,which is beneficial to the prognosis of precancerous lesions.