和中消萎汤联合常规用药治疗胃癌前病变临床研究

Clinical Study on Hezhong Xiaowei Tang Combined with Routine Medication for Precancerous Lesions of Gastric Cancer

目的:观察在常规用药基础上加用和中消萎汤治疗胃癌前病变(PLGC)肝胃气滞证的临床疗效。方法:将83例PLGC肝胃气滞证患者随机分为对照组42例和观察组41例。2组幽门螺杆菌(Hp)阳性患者均接受Hp根除治疗方案。对照组口服胃苏颗粒,观察组内服和中消萎汤,2组疗程均为16周。治疗前后评定胃脘疼痛、痞闷、纳差、嗳气、饱胀等症状评分,进行胃镜检查和胃黏膜组织病理检查,统计Hp阴转率。结果:治疗后,观察组疗效优于对照组,差异有统计学意义(P <0.05)。2组Hp阴转率比较,差异无统计学意义(P> 0.05)。2组症状、胃镜和病理评分均较治疗前下降(P <0.01),观察组3项评分均低于对照组(P <0.01)。结论:在常规用药基础上加用和中消萎汤能有效改善PLGC肝胃气滞证患者的临床症状,减轻胃黏膜的萎缩程度,有利于阻断或逆转PLGC。

Objective:To observe the clincal effect of the additional treatment of Hezhong Xiaowei tang based on routine medication for precancerous lesions of gastric cancer(PLGC)with qi stagnation in the liver and the stomach syndrome.Methods:A total of 83 cases of patients with PLGC with qi stagnation in the liver and the stomach syndrome were randomly divided into the control group(42 cases)and the observation group(41 cases).Patients with positive Helicobacter pylori(Hp)in the two groups received Hp eradication therapy.The control group received the oral administration of Weisu granules;the observation group was given Hezhong Xiaowei tang orally.The course of treatment in both groups was 16 weeks.The symptom scores of epigastric pain,distention and fullness,anorexia,belching as well as fullness were evaluated before and after treatment.Gastroscopy and pathological examination of gastric mucosa were performed,and Hp negative conversion rate was counted.Results:After treatment,the curative effect in the observation group was better than that in the control group,the difference being significant(P<0.05).There was no significant difference being found in the comparison of Hp negative conversion rate between the two groups(P>0.05).The scores of symptoms,the gastroscopy and the pathological examination in the two groups were decreased when compared with those before treatment(P<0.01),the three scores in the observation group were lower than those in the control group(P<0.01).Conclusion:The additional treatment of Hezhong Xiaowei tang based on routine medication can effectively improve the clinical symptoms of patients with PLGC with qi stagnation in the liver and the stomach syndrome,alleviate the atrophy of gastric mucosa and help to stop or reverse PLGC.