复方沙棘籽油栓结合干扰素α-2b栓治疗慢性宫颈炎伴高危型人乳头瘤病毒感染临床研究

Clinical Study on Compound Hippophae Rhamnoides Seed Oil Suppository Combined with Interferon α-2b Suppository for Chronic Cervicitis Accompanied by High-risk Human Papillomavirus Infection

目的:观察复方沙棘籽油栓结合干扰素α-2b栓治疗慢性宫颈炎伴高危型人乳头瘤病毒(HR-HPV)感染患者的临床效果。方法:选取106例慢性宫颈炎伴HR-HPV感染的患者,按治疗方式不同分成观察组和对照组各53例,2组均应用干扰素α-2b栓治疗,观察组加用复方沙棘籽油栓治疗,不间断进行3个疗程的治疗。对2组患者治疗结束后以及3个月后的白带量减少、白带脓性消失、宫颈糜烂面缩小的情况以及HPV转阴率进行统计。结果:治疗结束后,观察组的治愈率与总有效率均高于对照组(P <0.05),白带脓性消失率、宫颈糜烂面缩小率、白带量减少率与HPV转阴率略高于对照组,差异均无统计学意义(P> 0.05)。治疗结束后3个月,观察组白带脓性消失率、宫颈糜烂面缩小率与白带量减少率均高于对照组(P <0.05);2组的HPV转阴率均较3个月前有所下降,对照组下降的比例较大,观察组下降的比例较小,2组比较,差异无统计学意义(P> 0.05)。结论:采用复方沙棘籽油栓结合干扰素α-2b栓治疗慢性宫颈炎伴HR-HPV感染的效果优于单独用药,且远期疗效更显著。

Objective:To observe the clinical effect of compound hippophae rhamnoides seed oil suppository combined with interferonα-2 b suppository for chronic cervicitis accompanied by high-risk human papillomavirus(HR-HPV)infection.Methods:Selected 106 cases of patients with chronic cervicitis accompanied by HR-HPV infection,and divided them into the observation group and the control group according to their treatment methods,53 cases in each group.Both groups received interferonα-2 b suppository,while the observation group additionally received compound hippophae rhamnoides seed oil suppository.The treatment for both groups lasted for 3 courses continuously.Statistically analyzed such conditions as decrease in leukorrhea,disappearance of purulent leukorrhea and reduction in cervical erosion of both groups in the end of treatment and 3 months after treatment.Results:After treatment,the cure rate and total effective rate in the observation group were both higher than those in the control group(P<0.05),the disappearance rate of purulent leukorrhea,reduction rate of cervical erosion,decrease rate of leukorrhea and negative conversion rate of HPV in the observation group were slightly higher than those in the control group,differences being insignificant(P>0.05).3 months after treatment,the disappearance rate of purulent leukorrhea,reduction rate of cervical erosion and decrease rate of leukorrhea in the observation group were all higher than those in the control group(P<0.05),the negative conversion rate of HPV in both groups was lower than that 3 months ago,and the negative conversion rate of HPV in the control group was decreased more significantly than that in the observation group,difference being insignificant(P>0.05).Conclusion:The application of compound hippophae rhamnoides seed oil suppository combined with interferonα-2 b suppository has better effect than the simple medication in treating chronic cervicitis accompanied by HR-HPV infection,and its long-term clinical effect is more significant.