屈螺酮炔雌醇联合复方益母草膏在宫内早孕人工流产术后患者中的应用效果

Application Effect of Drospirenone and Ethinyl Estradiol Combined with Compound Motherwort Ointment on Patients with Early Intrauterine Pregnancy after Induced Abortion

目的:观察屈螺酮炔雌醇联合复发益母草膏治疗宫内早孕人工流产术后阴道出血的效果及对患者子宫内膜螺旋动脉血流动力学指标、相关细胞因子及雌二醇(E2)、孕激素(P)水平的影响。方法:将100例宫内早孕人工流产术后患者随机分为观察组及对照组,每组50例。对照组术后采用屈螺酮炔雌醇治疗,观察组采用屈螺酮炔雌醇联合复方益母草膏治疗。记录患者阴道出血情况,观察2组治疗前后子宫内膜螺旋动脉血流动力学指标、相关细胞因子及E2、P水平的变化。结果:阴道出血时间观察组(5.45±1.28)天,对照组(8.67±1.79)天,2组比较,差异有统计学意义(P <0.05)。观察组阴道出血量少于对照组,差异有统计学意义(P <0.05)。治疗后,2组4项子宫内膜螺旋动脉血流动力学指标均较治疗前改善(P <0.05);观察组4项子宫内膜螺旋动脉血流动力学指标改善情况均优于对照组(P <0.05)。治疗后,2组肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)、白细胞介素-2 (IL-2)水平均较治疗前降低(P <0.05);观察组TNF-α、IFN-γ及IL-2水平均低于对照组(P <0.05)。治疗后,2组白细胞介素-4 (IL-4)、白细胞介素-10 (IL-10)水平均较治疗前升高(P <0.05),白细胞介素-6 (IL-6)水平均较治疗前降低(P <0.05);观察组IL-4、IL-10水平均高于对照组(P <0.05),IL-6水平低于对照组(P <0.05)。治疗后,2组E2及P水平均较治疗前降低(P <0.05);观察组E2及P水平均低于对照组(P <0.05)。结论:屈螺酮炔雌醇联合复方益母草膏治疗宫内早孕人工流产术后患者,可减少阴道出血量,改善细胞因子及性激素水平。

Objective:To observe the clinical effect of drospirenone and ethinyl estradiol combined with compound motherwort ointment for vaginal bleeding in patients with early intrauterine pregnancy after induced abortion,and its effect on the hemodynamic parameters in endometrial spiral arteries,relevant cytokines and levels of estradiol(E2)and progesterone(P).Methods:Divided 100 cases of patients with early intrauterine pregnancy after induced abortion into the observation group and the control group randomly,50 cases in each group.The control group received drospirenone and ethinyl estradiol,while the observation group additionally received compound motherwort ointment.Recorded the occurrence of vaginal bleeding in patients,and observed the changes of hemodynamic parameters in endometrial spiral arteries,relevant cytokines and levels of E2 and P in both groups before and after treatment.Results:The vaginal bleeding time was(5.54±1.28)days in the observation group and(8.67±1.79)days in the control group,difference being significant(P<0.05).The vaginal bleeding volume in the observation group was smaller than that in the control group,difference being significant(P<0.05).After treatment,the four hemodynamic parameters in endometrial spiral arteries of patients in both groups were improved when comparing with those before treatment(P<0.05);the four hemodynamic parameters in endometrial spiral arteries of patients in the observation group were improved better than those in the control group(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)and interleukin-2(IL-2)in both groups were lower than those before treatment(P<0.05);the levels of TNF-α,IFN-γand IL-2 in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of interleukin-4(IL-4)and interleukin-10(IL-10)in both groups were higher than those before treatment(P<0.05),and the level of interleukin-6(IL-6)was lower than that before treatment(P<0.05);the levels of IL-4 and IL-10 in the observation group were higher than those in the control group(P<0.05),and the level of IL-6 was lower than that in the control group(P<0.05).After treatment,the levels of E2 and P in both groups were lower than those before treatment(P<0.05);the levels of E2 and P in the observation group were lower than those in the control group(P<0.05).Conclusion:Drospirenone and ethinyl estradiol combined with compound motherwort ointment for patients with early intrauterine pregnancy after induced abortion can reduce vaginal bleeding and improve cytokines and sex hormone levels.