凉血解毒方治疗原发性血小板减少性紫癜临床研究

Clinical Study of Liangxue Jiedu Prescription for Idiopathic Thrombocytopenic Purpura

目的:观察凉血解毒方治疗原发性血小板减少性紫癜(ITP)的效果,并分析对患者血小板及血小板相关抗体的影响。方法:将ITP患者76例随机分为2组各38例。对照组应用醋酸泼尼松龙片治疗。观察组在对照组基础上联合凉血解毒方治疗,治疗12周为1疗程。检测并比较2组患者治疗前后血小板计数(BPC)、血小板相关抗体(PAIgA、PAIgG、PAIgM)水平,对中医证候及体征进行分级评分,评价中西医疗效。结果:经治疗,对照组西医总有效率为65.79%,观察组西医总有效率为86.84%,观察组西医总有效率高于对照组(P <0.05)。对照组中医总有效率为71.05%,观察组中医总有效率为92.11%,观察组中医总有效率高于对照组(P <0.05)。2组患者BPC均随治疗时间呈升高趋势,且观察组BPC高于对照组,差异有统计学意义(P <0.05)。治疗前,对照组和观察组患者中医证候评分为(20.27±6.86)分、(20.50±6.53)分,差异无统计学意义(P> 0.05)。治疗后,观察组中医证候评分为(6.85±1.42)分低于对照组的(11.78±3.01)分,差异有统计学意义(P <0.05)。结论:对ITP患者采用凉血解毒方治疗,能够明显升高BPC,提高PAIgA、PAIgG、PAIgM表达,改善临床症状,效果确切。

Objective:To observe the effect of Liangxue Jiedu prescription for idiopathic thrombocytopenic purpura(ITP)and to analyze its effect on platelet and platelet associated immunoglobulin.Methods:A total of 76 cases of patients with ITP were randomly divided into two groups,38 cases in each group.The control group was treated with prednisolone acetate tablets,and the observation group was additionally treated with Liangxue Jiedu prescription based on the treatment of the control group,12 weeks of treatment being one course.The levels of blood platelet count(BPC),platelet associated immunoglobulin(PAIgA,PAIgG,PAIgM)in the two groups before and after treatment were detected and compared.The Chinese medicine syndromes and signs were given grading score and the curative effect of Chinese and western medicine was evaluated.Results:After treatment,the total effective rate of western medicine was 86.84%in the observation group,higher than that of 65.79%in the control group(P<0.05).The total effective rate of Chinese medicine was 92.11%in the observation group,higher than that of 71.05%in the control group(P<0.05).The BPC in both groups showed an increasing trend with the treatment time,and the BPC in the observation group was higher than that in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of Chinese medicine syndrome score in the control group and the observation group,which was respectively(20.27±6.86)and(20.50±6.53)(P>0.05).After treatment,the Chinese medicine syndrome score in the observation group(6.85±1.42)was lower than that in the control group(11.78±3.01),the difference being significant(P<0.05).Conclusion:The treatment of Liangxue Jiedu prescription for patients with ITP can significantly increase BPC and the expressions of PAIgA,PAIgG and PAIgM,and improve clinical symptoms with significant effect.