中药治疗单纯性肥胖机理研究进展

Research Progress on the Mechanism of Chinese Herbal Medicine for Simple Obesity

肥胖是全球性流行病,其中单纯性肥胖约占95%。西医在治疗单纯性肥胖上取得了一定的进展,但其应用有一定的局限性和较明显的不良反应。传统中医在肥胖病因及治疗上仍存在基础研究薄弱、疗效确定性不足等问题。近十年现代医学对肥胖的治疗包括增强瘦素(Leptin,LP)敏感性、调节脂肪代谢、调整肠道菌群、减轻胰岛素抵抗、增强基础代谢率等途径。笔者全面检索并分析国内外相关医学数据库关于用单味中药及方剂治疗单纯性肥胖的研究文献,旨在为本类药物的研究和开发提供参考。

Obesity is a global epidemic,in which the simple obesity accounts for about 95%.Some progress has been made in the treatment of simple obesity in western medicine,but there are some limitations and obvious adverse reactions in its application.There are still some problems in the etiology and the treatment of obesity in Chinese medicine,such as the weakness in the basic research and the insufficient certainty of the curative effect.The treatment of obesity in modern medicine in recent decades includes enhancing the sensitivity of leptin(LP),regulating lipid metabolism,adjusting the intestinal flora,reducing insulin resistance and enhancing the basal metabolic rate.The author comprehensively reviewed and analyzed the research literature on the treatment of simple obesity with single Chinese herbal medicine and prescriptions from relevant medical databases at home and abroad,in order to provide reference for the study and the development of this kind of medicine.