大黄牡丹汤治疗急腹症内毒素血症临床研究

Clinical Study on Dahuang Mudan Tang for Endotoxaemia Due to Acute Abdominal Diseases

目的:观察大黄牡丹汤治疗急腹症内毒素血症(ETM)的临床疗效。方法:将因急腹症术后发生ETM的89例患者随机分组,设为对照组45例与实验组44例,进行前瞻性研究。对照组常规给予补液抗感染治疗,实验组在抗感染补液基础上给予大黄牡丹汤中西医联合治疗,对比2组对ETM治疗效果。结果:治疗前2组患者每日排便次数比较,差异无统计学意义(P>0.05)。治疗后,2组患者每日排便次数均增多(P <0.05),2组每日排便次数比较,差异有统计学意义(P <0.05)。治疗前,2组血清ET水平比较,差异无统计学意义(P> 0.05)。治疗后,2组ET水平较前下降(P <0.05),2组血清ET比较,差异有统计学意义(P <0.05)。治疗前,2组TNF-α水平比较,差异无统计学意义(P> 0.05)。治疗后,2组TNF-α水平较前下降(P <0.05),2组TNF-α比较,差异有统计学意义(P <0.05)。结论:大黄牡丹汤联合西药治疗急腹症ETM,可更加有效降低患者血清ET,降低血清TNF-α水平,改善炎症介质的释放,提高大便次数,改善肠道功能,更有效保护患者肠黏膜,表明中西医联合治疗比传统西药更加有效,可提高患者预后。

Objective:To observe the clinical effect of Dahuang Mudan tang for endotoxaemia(ETM)due to acute abdominal diseases.Methods:Divided 89 cases of patients with ETM due to acute abdominal diseases into two groups randomly,45 cases in the control group and 44 cases in the experiment group.A prospective study was carried out.The control group received fluid infusion for anti-infection,while the experiment group additionally received Dahuang Mudan tang.Compared the clinical effect for ETM in both groups.Results:Before treatment,comparing the daily stool frequency in both groups,there was no significant difference being found(P>0.05).After treatment,the daily stool frequency in both groups was higher than that before treatment(P<0.05);comparing the daily stool frequency in-between the two groups,difference being significant(P<0.05).Before treatment,comparing the level of serum ET in both groups,there was no significant difference being found(P>0.05).After treatment,the level of serum ET in both groups was lower than that before treatment(P<0.05);comparing the level of serum ET in-between the two groups,difference being significant(P<0.05).Before treatment,comparing the level of TNF-αin both groups,there was no significant difference being found(P>0.05).After treatment,the level of TNF-αin both groups was lower than that before treatment(P<0.05);comparing the level of TNF-αin-between the two groups,difference being significant(P<0.05).Conclusion:Dahuang Mudan tang combined with western medicine for ETM due to acute abdominal diseases can decrease the levels of ET and TNF-αin serum of patients,improve the release of inflammatory mediators,increase stool frequency,improve intestinal function and protect the intestinal mucosa more effectively.It indicates that integrated Chinese and western medicine therapy is more effective than traditional western medicine,which can improve the prognosis of patients.