补阳还五汤加味联合常规西医疗法治疗冠心病心绞痛临床研究

Clinical Study on Modified Buyang Huanwu Tang Combined with Routine Western Medicine Therapy for Angina Pectoris

目的:分析补阳还五汤加味联合常规西医疗法治疗冠心病心绞痛的临床疗效。方法:选取冠心病心绞痛患者122例,按随机数字表法分为对照组和观察组各61例。对照组采用常规西医治疗,观察组在对照组基础上联合补阳还五汤加味治疗。比较2组临床疗效,统计中医证候积分,检测2组心脏功能和心肌酶水平变化。结果:治疗前,2组中医证候积分比较,差异无统计学意义(P> 0.05)。治疗后,2组疲倦乏力、胸闷、胸痛、心悸积分较治疗前显著降低(P <0.05),观察组疲倦乏力、胸闷、胸痛、心悸积分低于对照组(P <0.05)。治疗前,2组心功能指标水平比较,差异无统计学意义(P> 0.05)。治疗后,2组心输出量(CO)、心脏指数(CI)、射血分数(EF)水平较治疗前显著升高(P <0.05),观察组CO、CI、EF水平高于对照组(P <0.05)。治疗前,2组心肌酶水平比较,差异无统计学意义(P> 0.05)。治疗后,2组肌酸酶同工酶(CK-MB)、羟丁酸脱氢酶(HBDH)、乳酸脱氢酶(LDH)水平较治疗前显著降低(P <0.05),观察组CK-MB、HBDH、LDH水平低于对照组(P <0.05)。治疗前,2组超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、总抗氧化能力(T-AOC)、一氧化氮合酶(NOS)水平比较,差异无统计学意义(P> 0.05)。治疗后,2组SOD、GSH、T-AOC、NOS水平较治疗前显著升高(P <0.05),观察组SOD、GSH、T-AOC、NOS水平高于对照组(P <0.05)。结论:补阳还五汤加味联合常规西医疗法治疗冠心病心绞痛可改善患者临床症状和心功能,降低心肌酶水平,减轻氧化应激反应。

Objective:To analyze the clinical effect of modified Buyang Huanwu tang combined with routine western medicine therapy for angina pectoris.Methods:Selected 122 cases of patients with angina pectoris,and divided them into the control group and the observation group randomly,61 cases in each group.The control group received routine western medicine therapy,while the observation group additionally received modified Buyang Huanwu tang.Compared the clinical effect in both groups,statistically analyzed Chinese medicine syndrome scores,and detected the changes of cardiac functions and levels of myocardial enzymes before and after treatment in both groups.Results:Before treatment,comparing Chinese medicine syndrome scores in both groups,there was no significant difference being found(P>0.05).After treatment,the scores of fatigue,chest distress,chest pain and palpitation in both groups were significantly lower than those before treatment(P<0.05);each score above in the observation group was respectively lower than that in the control group(P<0.05).Before treatment,comparing the levels of cardiac function indexes in both groups,there was no significant difference being found(P>0.05).After treatment,the levels of cardiac output(CO),cardiac index(CI)and ejection fraction(EF)in both groups were significantly higher than those before treatment(P<0.05);the levels of CO,CI and EF in the observation group were respectively higher than those in the control group(P<0.05).Before treatment,comparing the levels of myocardial enzymes in both groups,there was no significant difference being found(P>0.05).After treatment,the levels of creatine kinase-MB(CK-MB),hydroxybutyrate dehydrogenase(HBDH)and lactate dehydrogenase(LDH)in both groups were significantly lower than those before treatment(P<0.05);the levels of CK-MB,HBDH and LDH in the observation group were respectively lower than those in the control group(P<0.05).Before treatment,comparing the levels of uperoxide dismutase(SOD),glutathione(GSH),total antioxidant capacity(T-AOC)and nitric oxide synthase(NOS)in both groups,there was no significant difference being found(P>0.05).After treatment,the levels of SOD,GSH,T-AOC and NOS in both groups were significantly higher than those before treatment(P<0.05);the levels of SOD,GSH,T-AOC and NOS in the observation group were respectively higher than those in the control group(P<0.05).Conclusion:Modified Buyang Huanwu tang combined with routine western medicine therapy for angina pectoris can improve the clinical symptoms and cardiac functions of patients,reduce levels of myocardial enzymes and alleviate oxidative stress reaction.