泰山磐石散治疗气血两虚型早期反复流产临床研究

Clinical Study on Taishan Panshi Powder for Early Recurrent Spontaneous Abortion of Dual Deficiency of Qi and Blood Type

目的:观察泰山磐石散治疗气血两虚型早期反复流产(ERSA)临床疗效及对患者孕酮的影响。方法:将60例气血两虚型ERSA患者随机分为西药组和中药组,每组30例。西药组给予地屈孕酮治疗,中医组给予泰山磐石散治疗,疗程均为3个月经周期,观察2组治疗前后月经周期情况及基础体温(BBT)变化情况,检测治疗前后血清卵泡刺激素(FSH)、黄体生成素(LH)、LH/FSH、睾丸酮(T)及孕酮(P)水平变化。结果:治疗后,中医组月经正常患者23例(76.67%),西药组10例(33.33%),2组比较,差异有统计学意义(P <0.05)。治疗后,中医组BBT双向患者22例(73.33%),西药组14例(46.67%),2组比较,差异有统计学意义(P <0.05)。治疗后2组血清LH、FSH、LH/FSH、T、P水平均较治疗前改善(P <0.05),且中医组LH、LH/FSH、T、P等指标改善较西药组更显著(P <0.05)。结论:泰山磐石散能有效改善气血两虚型ERSA患者月经情况及激素水平,疗效优于地屈孕酮治疗,值得临床推广应用。

Objective:To observe the clinical effect of Taishan Panshi powder for early recurrent spontaneous abortion(ERSA)of dual deficiency of qi and blood type and its effect on progesterone in patients.Methods:A total of 60 cases of ERSA patients of dual deficiency of qi and blood type were randomly divided into the western medicine group and the Chinese medicine group,30 cases in each group.The western medicine group was treated with dydrogesterone,and the Chinese medicine group was treated with Taishan Panshi powder.Both groups were treated for three menstrual cycles.The menstrual cycles and the changes of basal body temperature(BBT)before and after treatment in the two groups were observed,and the changes of the levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),LH/FSH,testosterone(T)and progesterone(P)in serum before and after treatment were detected.Results:After treatment,there were 23 cases of patients with eumenorrhea in the Chinese medicine group(76.67%),and 10 cases in the western medicine group(33.33%),the difference being significant(P<0.05).After treatment,there were 22 cases of patients with two-phase BBT in the Chinese medicine group(73.33%),and 14 cases in the western medicine group(46.67%),the difference being significant(P<0.05).After treatment,the levels of LH,FSH,LH/FSH,T and P in serum in the two groups were improved when compared with those before treatment(P<0.05),and the levels of LH,LH/FSH,T and P in the Chinese medicine group were improved more significantly than those in the western medicine group(P<0.05).Conclusion:Taishan Panshi powder can effectively improve the menstruation and the levels of hormones in ERSA patients of dual deficiency of qi and blood type,whose curative effect is better than that of dydrogesterone,and is worthy of clinical promotion and application.