丹参川芎嗪注射液治疗冠心病不稳定型心绞痛临床研究

Clinical Study on Danshen Chuanxiongqin Injection for Unstable Angina Pectoris of Coronary Heart Disease

目的:观察丹参川芎嗪注射液治疗冠心病不稳定型心绞痛的临床疗效及其对血清N末端B型钠尿肽(NT-proBNP)、超敏C-反应蛋白(hs-CRP)的影响。方法:将136例患者随机分为2组,对照组68例行常规治疗,观察组68例在对照组治疗的基础上加用丹参川芎嗪注射液静脉滴注,2组疗程均为3周,观察2组临床疗效以及治疗前后患者中医症状积分、NTproBNP与hs-CRP水平。结果:总有效率观察组为97.06%,对照组为79.41%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组患者胸闷、胸痛、气短喘促、心悸症状积分均较治疗前降低(P <0.05),且观察组上述各项积分均低于对照组(P<0.05)。治疗后,2组血清hs-CRP、NT-proBNP水平均较治疗前降低(P <0.05),且观察组hs-CRP、NT-proBNP水平低于对照组(P <0.05)。结论:丹参川芎嗪注射液治疗冠心病不稳定型心绞痛可提高临床疗效,改善患者临床症状,下调NT-proBNP、hs-CRP水平。

Objective:To observe the clinical effect of Danshen Chuanxiongqin injection for unstable angina pectoris of coronary heart disease,and its effect on N-terminal pro-B-type natriuretic peptide(NT-pro BNP)and hypersensitive C-reactive protein(hs-CRP)in serum.Methods:Divided 136 cases of patients into two groups randomly,68 cases in each group.The control group received routine treatment,while the observation group additionally received Danshen Chuanxiongqin injection via intravenous drip.The treatment of both groups lasted for 3 weeks.Observed the clinical effect in both groups,and evaluated Chinese medicine syndrome scores and the levels of NT-pro BNP and hs-CRP in serum of patients before and after treatment.Results:The total effective rate was 97.06%in the observation group and 79.41%in the control group,difference being significant(P<0.05).After treatment,the scores of such symptoms as chest distress,chest pain,short breath and heavy wheezing,and palpitation in both groups were all lower than those before treatment(P<0.05),and each score above in the observation group was lower than that in the control group(P<0.05).After treatment,the levels of NT-pro BNP and hs-CRP in serum of patients in both groups were lower than those before treatment(P<0.05),and the levels of NT-pro BNP and hs-CRP in the observation group were lower than those in the control group(P<0.05).Conclusion:Danshen Chuanxiongqin injection for unstable angina pectoris of coronary heart disease can promote the clinical effect,improve the clinical symptoms of patients,and down-regulate the levels of NT-pro BNP and hs-CRP.