麦杏补肺汤联合西药治疗慢性阻塞性肺疾病稳定期肺气虚证临床研究

Clinical Study on Maixing Bufei Tang Combined with Western Medicine for Chronic Obstructive Pulmonary Disease with Lung Qi Deficiency Syndrome at Stable Stage

目的:观察麦杏补肺汤联合西药治疗慢性阻塞性肺疾病(COPD)稳定期肺气虚证的临床疗效。方法:选取110例COPD稳定期肺气虚证患者,按随机数字表法分为对照组和研究组各55例。对照组给予常规西药治疗,研究组在对照组治疗基础上加用麦杏补肺汤,2组均治疗12周。对比分析2组临床疗效,观察患者肺功能和免疫功能的改善情况。结果:总有效率研究组96.36%,对照组83.64%,2组比较,差异有统计意义(P <0.05)。治疗后,2组第1秒用力呼气量(FEV1)、用力肺活量(FVC)、FEV1/FVC均较治疗前改善(P <0.05);研究组3项肺功能指标均比对照组改善更明显(P <0.05)。治疗后,2组降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、CD8^+水平均较治疗前降低(P <0.05),CD4^+水平均较治疗前升高(P <0.05);研究组PCT、TNF-α、CD8^+水平均低于对照组(P <0.05),CD4^+水平高于对照组(P <0.05)。结论:在COPD稳定期肺气虚证患者临床治疗中加用麦杏补肺汤可提高临床疗效,改善患者的肺功能,减少炎性因子,提升机体免疫功能。

Objective:To observe the clinical effect of Maixing Bufei tang combined with western medicine for chronic obstructive pulmonary disease(COPD)with lung qi deficiency syndrome at stable stage.Methods:A total of 110 cases of patients with COPD with lung qi deficiency syndrome at stable stage were divided into the control group and the study group according to the random number table method,55 cases in each group.The control group was treated with routine western medicine,and the study group was additionally treated with the Maixing Bufei tang based on the treatment of the control group.Both groups were treated for 12 weeks.The clinical effect in the two groups were compared and analyzed,and the improvement of the lung function and the immune function of patients were observed.Results:The total effective rate was 96.36%in the study group,and 83.64%in the control group,the difference being significant(P<0.05).After treatment,the forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and FEV1/FVC in the two groups were better than those before treatment(P<0.05);the above three indexes concerning the lung function in the study group were improved more obviously than those in the control group(P<0.05).After treatment,the levels of procalcitonin(PCT),tumor necrosis factor-α(TNF-α)and CD8+in the two groups were decreased when compared with those before treatment(P<0.05),while the levels of CD4+in the two groups were increased when compared with those before treatment(P<0.05);the levels of PCT,TNF-αand CD8+in the study group were lower than those in the control group(P<0.05),while the level of CD4+in the study group was higher than that in the control group(P<0.05).Conclusion:The additional application of Maixing Bufei tang in the clinical treatment of patients with COPD with lung qi deficiency syndrome at stable stage can improve the clinical effect and their lung function,reduce inflammatory factors and enhance the immune function.