疏肝清胆汤加减治疗肝胆湿热型慢性胆囊炎临床研究

Clinical Study of Modified Shugan Qingdan Tang for Chronic Cholecystitis of Dampness Heat in Liver and Gallbladder type

目的:观察疏肝清胆汤加减治疗肝胆湿热型慢性胆囊炎临床疗效。方法:选取96例肝胆湿热型慢性胆囊炎患者,随机均分为2组。对照组采用利胆片治疗;观察组采用疏肝清胆汤加减治疗,连续治疗4周为1个疗程。评价患者的证候评分以及临床疗效,并检测血脂和总胆汁酸的含量。结果:治疗后,观察组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)以及总胆汁酸(TBA)的水平含量均低于对照组,高密度脂蛋白胆固醇(HDL-C)含量高于对照组,差异均有统计学意义(P <0.05)。观察组主症和次症评分均低于对照组,差异均有统计学意义(P <0.05)。观察组总有效率高于对照组,差异有统计学意义(P <0.05)。结论:采用疏肝清胆汤治疗肝胆湿热型慢性胆囊炎,能通过调节血脂和总胆汁酸水平,从而明显改善临床症状,效果确切。

Objective:To observe the clinical effect of modified Shugan Qingdan tang for chronic cholecystitis of dampness heat in liver and gallbladder type.Methods:Selected 96 cases of patients with chronic cholecystitis of dampness heat in liver and gallbladder type,and divided them into two groups randomly,48 cases in each group.The control group received cholagogic tablets,while the observation group received modified Shugan Qingdan tang.The treatment for both groups lasted for one course,4 weeks as one course.Evaluated Chinese medicine syndrome scores and the clinical effect of patients in both groups,and detected the contents of blood lipid and total bile acid.Results:After treatment,the contents of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and total bile acid(TBA)in the observation group were respectively lower than those in the control group,and the content of high density lipoprotein cholesterol(HDL-C)was higher than that in the control group,differences being significant(P<0.05).The scores of major syndrome and minor syndrome in the observation group were respectively lower than those in the control group,differences being significant(P<0.05).The total effective rate in the observation group was higher than that in the control group,difference being significant(P<0.05).Conclusion:The application of modified Shugan Qingdan tang has exact effect in treating chronic cholecystitis of dampness heat in liver and gallbladder type by regulating the levels of blood lipid and total bile acid so as to significantly improve the clinical symptoms.