妇乐片联合西药治疗慢性盆腔炎临床研究

Clinical Study on Fule Tablets Combined with Western Medicine for Chronic Pelvic Inflammation Disease

目的:观察妇乐片治疗慢性盆腔炎(CPID)的临床疗效及对炎症因子的影响。方法:将CPID患者90例随机分为观察组和对照组,各45例;对照组给予盐酸左氧氟沙星注射液、甲硝唑注射液静脉滴注,观察组在对照组治疗的基础上加用妇乐片口服;2组疗程均为7天,观察患者临床疗效及治疗前后血清肿瘤坏死因子(TNF-α)、白细胞介素10 (IL-10)水平、中医症状积分变化,并比较不良反应发生情况。结果:临床总有效率观察组为91.11%,对照组为77.78%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组患者血清TNF-α水平较治疗前明显降低(P <0.05),而IL-10水平升高(P <0.05);且观察组上述指标改善明显优于对照组(P <0.05)。治疗后,2组患者腹痛、白带异常、小便色黄、痛经、附件压痛等症状积分均显著降低(P <0.05),且观察组上述各项积分低于对照组(P <0.05)。不良反应发生率观察组为4.44%,对照组为11.11%,2组比较,差异有统计学意义(P <0.05)。结论:妇乐片治疗CPID具有良好的临床疗效,能明显下调TNF-α表达,上调IL-10表达,从而改善患者微炎状态。

Objective:To observe the clinical effect of Fule tablets for chronic pelvic inflammation disease(CPID)and its effect on inflammatory factors.Methods:A total of 90 cases of CPID patients were randomly divided into the observation group and the control group,45 cases in each group.The control group was given levofloxacin hydrochloride injection and metronidazole injection by intravenous drips,and the observation group additionally received oral administration of Fule tablets based on the treatment of the control group.Both groups were treated for seven days.The clinical effect,the levels of tumor necrosis factor-α(TNF-α)and interleukin-10(IL-10)in serum as well as the changes of Chinese medicine symptom scores before and after treatment were observed,and the adverse reactions were compared.Results:The total clinical effective rate was 91.11%in the observation group and 77.78%in the control group,the difference being significant(P<0.05).After treatment,the levels of TNF-αin serum in the two groups were significantly decreased when compared with those before treatment(P<0.05),while the levels of IL-10 were increased(P<0.05);the improvement of the above indexes in the observation group was significantly better than that in the control group(P<0.05).After treatment,the symptom scores including abdominal pain,abnormal leukorrhea,yellow urine,dysmenorrhea and tenderness on the appendages in the two groups were significantly decreased(P<0.05),and the above scores in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions was 4.44%in the observation group and 11.11%in the control group,the difference being significant(P<0.05).Conclusion:Fule tablets have significant clinical effect in treating CPID,and can obviously down-regulate the expression of TNF-αand up-regulate the expression of IL-10,thus improving the state of micro-inflammation.