解毒退黄汤治疗新生儿感染性黄疸临床疗效及对PCT、CRP水平的影响

Clinical Observation on Effect of Jiedu Tuihuang Tang on Levels of PCT and CRP in Newborns with Infectious Jaundice

目的:探讨解毒退黄汤对新生儿感染性黄疸患儿降钙素原(PCT)、C-反应蛋白(CRP)水平的影响。方法:采用简单随机抽样法将90例新生儿感染性黄疸(胎黄邪毒证)患儿分为对照组和观察组,每组45例。对照组给予高压氧治疗,观察组在对照组基础上给予解毒退黄汤,2组均以5天为1个疗程;比较2组临床疗效、治疗前后中医证候积分及血清总胆红素、游离胆红素、PCT、CRP等水平。结果:治疗后,2组治疗有效率比较,差异无统计学意义(P> 0.05)。观察组治愈率为60.00%,对照组为33.33%,2组治愈率比较,差异有统计学意义(P <0.05)。治疗前,2组中医证候积分比较,差异无统计学意义(P>0.05)。治疗后,2组中医证候积分较治疗前降低(P <0.05),观察组低于对照组(P <0.05)。治疗前,2组血清总胆红素、游离胆红素、PCT、CRP水平比较,差异无统计学意义(P> 0.05)。治疗后,2组血清总胆红素、游离胆红素、PCT、CRP水平较治疗前降低(P <0.05),且观察组上述指标低于对照组(P <0.05)。2组治疗期间均无严重不良反应。结论:解毒退黄汤辅助治疗新生儿感染性黄疸(胎黄邪毒证)疗效显著,能够有效改善中医证候积分,降低血清胆红素水平,其机制可能与下调PCT、CRP有关。

Objective:To discuss the effect of Jiedu Tuihuang tang on the levels of procalcitonin(PCT)and C-reactive protein(CRP)in newborns with infectious jaundice.Methods:A total of 90 newborns with infectious jaundice with neonatal jaundice and pathogenic toxin syndrome were divided into the control group and the observation group according to the simple random sampling method,45 cases in each group.The control group was given hyperbaric oxygen for treatment,and the observation group was given Jiedu Tuihuang tang based on the treatment of the control group.Both groups were treated for one course,five days being a course.The clinical effect,the Chinese medicine syndrome scores and the levels of total bilirubin,unconjugated bilirubin,PCT and CRP in serum before and after treatment in the two groups were compared.Results:After treatment,there was no significant difference being found in the comparison of the effective rates of treatment in the two groups(P>0.05).The cure rate was 60.00%in the observation group and 33.33%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of the Chinese medicine syndrome scores of the two groups(P>0.05).After treatment,the Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the score in the observation group was lower than that in the control group(P<0.05).Before treatment,compared the levels of total bilirubin,unconjugated bilirubin,PCT and CRP in serum of the two groups,there was no significance in the difference(P>0.05).After treatment,the levels of total bilirubin,unconjugated bilirubin,PCT and CRP in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the above indexes in the observation group were lower than those in the control group(P<0.05).No serious adverse reaction was found in the two groups during the treatment.Conclusion:The adjuvant therapy of Jiedu Tuihuang tang has significant curative effect in treating infectious jaundice with neonatal jaundice and pathogenic toxin syndrome in newborns,which can effectively improve the Chinese medicine syndrome scores and reduce the level of bilirubin in serum.Its mechanism may be related to the down-regulation of PCT and CRP.