解毒养阴含漱液联合常规医护措施治疗复发性口疮临床研究

Clinical Study on Yin-nourishing and Toxin-eliminating Gargle Combined with Routine Nursing Measures for Recurrent Aphthous Ulcer

目的:观察解毒养阴含漱液联合常规医护措施治疗复发性口疮(ROU)的近期临床疗效。方法:将120例ROU心脾积热证患者按随机数字表法分为对照组和观察组各60例。2组均给予复合维生素BC片和胸腺肽肠溶片内服,并给予含漱方法、饮食护理、口腔卫生护理、心理护理和生活习惯指导等综合护理措施。对照组采用康复新液适量含漱,观察组给予解毒养阴含漱液适量含漱。2组均连续治疗7天。每天采用疼痛数字评分法(NRS)评定疼痛程度,记录口腔疼痛消失时间和口腔溃疡愈合时间,治疗前后采用口腔健康影响程度量表(OHIP-14)评价患者的生活质量,并评定局部症状体征评分。结果:治疗后,观察组临床疗效优于对照组(P <0.05)。观察组疼痛消失时间和溃疡愈合时间均短于对照组(P <0.01)。观察组NRS评分、OHIP-14评分和局部症状体征评分均低于对照组(P <0.01)。结论:解毒养阴含漱液联合常规综合医护措施可明显缩短ROU病程,有效减轻疼痛,促进溃疡的愈合,提高患者的生活质量,短期疗效显著。

Objective:To observe the short-term clinical effect of yin-nourishing and toxin-eliminating gargle combined with routine nursing measures for recurrent aphthous ulcer(ROU).Methods:Divided 120 cases of ROU patients with syndrome of heat retention due to heart deficiency into the control group and the observation group according to random number table,60 cases in each group.Both groups were given multivitamin BC tablets and thymosin enteric-coated tablets orally as well as comprehensive nursing measures including gargle method,diet nursing,oral hygiene nursing,psychological nursing and living habits guidance.The control group was treated with Kangfuxin solution for gargle,and the observation group was given appropriate amount of yin-nourishing and toxin-eliminating gargle.Both groups were treated continuously for7 days.Assessed the pain degree every day by using the numeric rating scale(NRS),recorded the disappearance time of oral pain and the healing time of oral ulcer,and evaluated the quality of life of patients by oral health impact scale(OHIP-14)before and after treatment and assessed the local symptom and sign scores.Results:After treatment,the clinical effect of the observation group was better than that of the control group(P<0.05).The disappearance time of pain and healing time of ulcer in the observation group were shorter than those in the control group(P<0.01).The NRS score,OHIP-14 score and local symptom and sign scores in the observation group were lower than those in the control group(P<0.01).Conclusion:The application of yin-nourishing and toxin-eliminating gargle combined with routine nursing measures can significantly shorten the ROU course,effectively alleviate pain,promote ulcer healing and improve quality of life of patients.It has obvious short-term curative effect.